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Induction of Hypomanic Episode With Transcranial Direct Current Stimulation

Arul-Anandam, Abraham Patrick*; Loo, Colleen MD, FRANZCP*†; Mitchell, Philip MD, FRANZCP*†

doi: 10.1097/YCT.0b013e3181a744bf
Case Reports

We report on the case of a 57-year-old man who experienced an episode of hypomania while participating in a clinical trial of transcranial direct current stimulation for the treatment of major depressive disorder. Although hypomania and mania have been reported after transcranial magnetic stimulation to the dorsolateral prefrontal cortex in the past, to our knowledge, this is the first report of mania after transcranial direct current stimulation to the dorsolateral prefrontal cortex.

From the *School of Psychiatry, University of New South Wales; and †Black Dog Institute; Sydney, Australia.

Received for publication December 19, 2008; accepted March 23, 2009.

Reprints: Colleen Loo, MD, Black Dog Institute, Prince of Wales Hospital, Barker St, Randwick 2031, Sydney, Australia (e-mail:

© 2010 Lippincott Williams & Wilkins, Inc.