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Successful Use of Donepezil in Treatment of Cognitive Impairment Caused by Maintenance Electroconvulsive Therapy: A Case Report

Rao, Naren P. MBBS, MD*; Palaniyappan, Pradeep MBBS*; Chandur, Jyothsna M Phil; Venkatasubramanian, Ganesan MBBS, MD*; Gangadhar, Bangalore N. MBBS, MD*

doi: 10.1097/YCT.0b013e3181926ada
Case Reports

Cognitive deficits are commonly associated with maintenance electroconvulsive therapy (ECT). Treatment of these cognitive deficits is important but difficult. Cholinergic pathways are involved in these side effects, and donepezil, a cholinesterase inhibitor, may be useful for improvement of cognition. In this case report, we describe for the first time successful use of donepezil in treating cognitive deficits associated with maintenance ECT. The role of cholinesterase inhibitors in the treatment of cognitive deficits caused by ECT needs further studies.

From the Departments of *Psychiatry and †Mental Health and Social Psychology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Received for publication September 26, 2008; accepted October 22, 2008.

Reprints: Ganesan Venkatasubramanian, MD, National Institute of Mental Health and Neurosciences, Hosur Rd, Bangalore-560029, India (e-mail:;

© 2009 Lippincott Williams & Wilkins, Inc.