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Efficacy of Electroconvulsive Therapy in Fahr Disease Associated With Bipolar Psychotic Disorder: A Case Report

Casamassima, Francesco MD*†; Lattanzi, Lorenzo MD*; Perlis, Roy H. MD, MSc†‡; Fratta, Sara MD*; Litta, Antonella MD*; Longobardi, Antonio MD*; Stange, Jonathan P. BA; Tatulli, Alessandro MD*; Cassano, Giovanni B. MD*

doi: 10.1097/YCT.0b013e3181914d28
Case Reports

We report a case of a patient with Fahr disease affected by bipolar disorder type I with psychotic symptoms. The complex clinical picture, characterized by both neurological and psychiatric symptoms, proved to be partially or completely resistant to several pharmacological trials. On the contrary, a marked improvement of clinical picture occurred after a cycle of 10 sessions of electroconvulsive therapy, followed by a complete and sustained resolution of mood, cognitive, motor, and behavioral symptoms during the next 4 years.

From the *Division of Psychiatry, University of Pisa, Pisa, Italy; †Department of Psychiatry, Massachusetts General Hospital; and ‡Department of Psychiatry, Harvard Medical School, Boston, MA.

Received in October 7, 2008; Accepted for publication October 10, 2008.

Reprints: Francesco Casamassima, MD, Dipartimento di Psichiatria, University of Pisa, Via Roma, 67, 56100 Pisa, Italy (e-mail:,

© 2009 Lippincott Williams & Wilkins, Inc.