Original StudiesBifrontal Versus Bitemporal Electroconvulsive Therapy in Severe Manic PatientsBarekatain, Majid MD; Jahangard, Leila MD; Haghighi, Mohammad MD; Ranjkesh, Farzad MDAuthor Information From the Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran. Received for publication September 9, 2007; accepted November 13, 2007. Reprints: Majid Barekatain, MD, Behavioral Sciences Research Center, Noor University Hospital, Ostandari St, Isfahan, Iran (e-mail: [email protected]). The Journal of ECT: September 2008 - Volume 24 - Issue 3 - p 199-202 doi: 10.1097/YCT.0b013e3181624b5d Buy Metrics Abstract Objectives: To compare the efficacy and safety of moderate-dose bifrontal (BF) with low-dose bitemporal (BT) electroconvulsive therapy (ECT) in the treatment of patients with severe mania. Methods: In a parallel, double-blind, randomized clinical trial, 28 patients with severe mania admitted to a university hospital were assigned randomly to moderate-dose BF (n = 14) and low-dose BT (n= 14) ECT. The primary outcome measures included the Mini-Mental State Examination (MMSE) and the Young Mania Rating Scale (YMRS). Results: All patients received at least 6 sessions of ECT. The 2 groups did not show any difference in their baseline MMSE or YMRS scores (P > 0.05). There was a significant difference between the MMSE scores of the BF compared with the BT group after both the sixth ECT (P < 0.05) and final ECT treatments (P < 0.05). Young Mania Rating Scale scores did not differ between the 2 groups after either the sixth or the last ECT sessions (P > 0.05). Conclusions: Moderate-dose BF ECT was as effective as BT ECT but was associated with fewer cognitive side effects in the treatment of patients with severe mania. © 2008 Lippincott Williams & Wilkins, Inc.