Original StudyChange in Seizure Threshold During Electroconvulsive TherapyFink, Max MD*; Petrides, Georgios MD*†; Kellner, Charles MD†; Mueller, Martina PhD‡; Knapp, Rebecca PhD‡; Husain, Mustafa M. MD§; Rasmussen, Keith MD∥; Rummans, Teri MD∥; O'Connor, Kevin MD†the CORE GroupAuthor Information From the *Long Island Jewish-Hillside Hospital, Glen Oaks, NY; †University of Medicine and Dentistry of New Jersey, Newark, NJ; ‡Medical University of South Carolina, Charleston, SC; §University of Texas Southwestern Medical School, Dallas, TX; and ∥MAYO Clinic, Rochester, MN. CORE: Consortium for Research in ECT. Received for publication August 10, 2007; accepted September 19, 2007. Reprints: Max Fink, MD, PO Box 457, St James, NY 11780 (e-mail: firstname.lastname@example.org). The Journal of ECT: June 2008 - Volume 24 - Issue 2 - p 114-116 doi: 10.1097/YCT.0b013e31815f65b9 Buy Metrics Abstract The seizure threshold (ST) is a measure of the minimum electrical energy necessary to induce a grand mal seizure. Dose titration of the ST has been suggested to optimize stimulus dosing in electroconvulsive therapy (ECT). The change in ST with remission is examined in a large sample of unipolar depressed patients. Methods: In a study of continuation treatments after successful ECT, the ST was determined at the first treatment and again 1 week after remission using a conventional ST measurement protocol. Patients were treated with bilateral electrode placement at 150% above the measured ST. Results: In 80 subjects, the ST measured the same in 70%, increased in 21%, and decreased in 9% at remission. Conclusions: In a study of bilateral ECT, the ST did not rise conclusively with remission. © 2008 Lippincott Williams & Wilkins, Inc.