Original StudyA Comparison of Propofol and Thiopentone Use in Electroconvulsive Therapy: Cognitive and Efficacy EffectsIngram, Anna BA(Hons)*†‡; Schweitzer, Isaac MD†‡; Ng, Chee H. MD†‡; Saling, Michael M. PhD*; Savage, Greg PhD†§Author Information From the *Departments of Psychology and †Psychiatry, The University of Melbourne; ‡The Professorial Unit, The Melbourne Clinic, Richmond, Victoria and §Macquarie Centre for Cognitive Science (MACCS), Macquarie University, Sydney, Australia. There was no conflict of interest in financial support for this research. Received for publication November 17, 2006; accepted April 13, 2007. Reprints: Anna Ingram, BA(Hons), The Professorial Unit, The Melbourne Clinic, 130 Church St, Richmond, Victoria 3121, Australia (e-mail: Anna.Ingram@healthscope.com.au). The Journal of ECT: September 2007 - Volume 23 - Issue 3 - p 158-162 doi: 10.1097/yct.0b013e318070d1e9 Buy Metrics Abstract Objective: The purpose of this study was to compare thiopentone and propofol administration for electroconvulsive therapy (ECT) in terms of associated efficacy and cognitive side effects in the immediate and medium term. Method: Participants comprised 30 depressed patients who were administered either propofol or thiopentone as an anesthetic agent for ECT. Clinical rating scales and a battery of neuropsychological tests were administered at baseline, after 6 treatments, 1 to 3 days after treatment end point, and at 1-month follow-up. Results: Thiopentone administration was associated with advantages in efficacy and cognitive side effects compared with propofol administration. Conclusions: This study reports some serendipitous findings regarding the comparative effects of the anesthetic agents, propofol and thiopentone. Although limited by small sample size, results suggest that thiopentone has advantages for use as an anesthetic agent with ECT compared with propofol. It also highlights the need for further investigation of the impact of anesthetic agents on the cognitive side effects and efficacy of ECT. © 2007 Lippincott Williams & Wilkins, Inc.