Original ArticlesThe Impact of Clinically Diagnosed Personality Disorders on Acute and One-Year Outcomes of Electroconvulsive TherapySareen, Jitender M.D; Enns, Murray W. M.D; Guertin, Jennith E. B.AAuthor Information Department of Psychiatry, University of Manitoba, Winnipeg; and the Mood Disorders Program, Health Sciences Centre, Winnipeg, Manitoba, Canada Received November 3, 1998; accepted February 3, 1999. Address correspondence and reprint requests to Dr. M. W. Enns, PZ-430 PsycHealth Centre, University of Manitoba, 771 Bannatyne Avenue, Winnipeg, MB, Canada, R3E 3N4. The Journal of ECT: March 2000 - Volume 16 - Issue 1 - p 43-51 Buy Abstract Clinical experience suggests that patients with depression and a comorbid personality disorder (PD) may have a poorer response to electroconvulsive therapy (ECT). Only a few published studies have examined the relationship between comorbid personality disorders and response of major depression to ECT. These studies have used relatively small numbers of patients. The present study is a retrospective review of 107 inpatients with a major depressive episode referred for ECT. Patients with a clinically diagnosed PD, especially a cluster B PD, had a significantly poorer acute response to ECT than those without a PD. During the first year after treatment, ECT responders with a comorbid PD had a higher rate of relapse of depression. The retrospective study design limits the strength of conclusions that can be drawn. Nevertheless, it appears that clinically diagnosed PDs may be predictive of poor outcome in patients receiving ECT for depression. Further prospective study of the relationship between both clinically diagnosed PDs and structured interview based PD diagnoses and ECT treatment response is warranted. © 2000 Lippincott Williams & Wilkins, Inc.