Article: PDF OnlyThe Effect of Short-Term Electroconvulsive Treatment Plus Neuroleptics in Treatment-Resistant Schizophrenia and Schizoaffective DisorderSajatovic, M. M.D.; Meltzer, H. Y. M.D.Author Information Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, U.S.A. Convulsive Therapy: September 1993 - Volume 9 - Issue 3 - p 167-175 Buy Abstract The effect of electroconvulsive therapy (ECT) plus loxapine in nine patients with treatment-refractory schizophrenia or schizoaffective disorder was studied in an open trial. Five of the nine patients (55.6%) improved significantly (≥20%) in the Brief Psychiatric Rating Scale total scores by the end of the course of ECT. Improvement was greater in positive than in negative symptoms. A sixth patient improved 3–6 weeks after the completion of the acute course of ECT. Five patients who responded to ECT received maintenance ambulatory ECT; two patients remained improved for at least 6–9 months, whereas the other three relapsed within 4 months. Further study of the indications for and the effectiveness of ECT plus neuroleptic drugs in treatment-resistant schizophrenia is indicated. © Lippincott-Raven Publishers.