Emergency and Critical Care Medicine

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​​​​​​​​​Instructions for Authors

The Editorial Office is pleased to answer any questions you may have about preparing your manuscript in accordance with our guidelines.

Email: [email protected]


Emergency and Critical Care Medicine is an open access, peer-reviewed, international medical journal dedicated to improving the quality of care by publishing basic and clinical cutting-edge findings in emergency, critical care and related medical specialties.

Contributions are welcome from emergency and critical care professionals and researchers, with research areas including but not limited to the followings: cardiopulmonary resuscitation, acute cardiovascular diseases, stroke, shock, acute respiratory failure, infection, trauma, out-of-hospital emergency medical services, emergency, critical care, disaster management, toxicology, organ dysfunction, artificial intelligence, life-supporting devices, etc.

We publish the following article types: original articles, reviews, case reports, meta-analysis, comments, methodologies, perspectives/viewpoints, editorials, images, news, communications, letters to the editor, etc.

Emergency and Critical Care Medicine is an official journal of Shandong University (https://www.en.sdu.edu.cn/​), funded by the “High-level New Journal of 2019 Action Plan for the Excellence of China Science and Technology Journals” project, supported by Chinese Society of Emergency Medicine (https://csem.cma.org.cn/) as well as Chest Pain Branch of China International Exchange and Promotive Association for Medical and Health Care (https://www.cpam.org.cn/​).​​


All manuscripts should be submitted online at: https://www.editorialmanager.com/eccm/

First-time users

Please click the Register button at https://www.editorialmanager.com/eccm/. Upon successful registration, you will be sent an email providing your username and password. Save this information for future reference. Note: If you have received an email from us with an assigned username and password, or if you are a repeat user, do not register again. Once you have an assigned username and password, you do not have to re-register.


Please click the Login button from the menu at the top of the page and login to the system as an author. Submit your manuscript according to the author instructions. You will be able to track the process of your manuscript through the system.


Duplicate Publication

Manuscripts are reviewed for possible publication with the understanding that they are being submitted only to the Emergency and Critical Care Medicine and have not been published, simultaneously submitted, or already accepted for publication elsewhere. The Editorial team may subject any manuscript submitted for consideration of publication in Emergency and Critical Care Medicine to plagiarism-detection software.

This does not preclude consideration of a manuscript that has been rejected by another journal or a complete report that follows publication of preliminary findings elsewhere, usually in the form of an abstract. Copies of any possibly duplicate published material should be submitted with the manuscript under consideration, with a statement in the cover letter as to why the manuscript currently being submitted is not a duplicate publication.

Disclosure of Conflicts

Authors must state all possible conflicts of interest in the manuscript, including financial, consultant, institutional and other relationships that might lead to bias or a conflict of interest. If there is no conflict of interest, this should also be explicitly stated as none declared. All sources of funding should be acknowledged in the manuscript. All relevant conflicts of interest and sources of funding should be included on the title page of the manuscript with the heading "Conflicts of Interest and Source of Funding:". For example: “Conflicts of Interest and Source of Funding: A has received honoraria from Company Z. B is currently receiving a grant (#12345) from Organization Y, and is on the speaker's bureau for Organization X - the CME organizers for Company A. For the remaining authors none were declared."

Data Availability Statement​

Emergency and Critical Care Medicine requires authors to include in any articles that report results derived from research data to include a Data Availability Statement from October 1, 2022The provision of a Data Availability Statement will be verified as a condition of publication. Data Availability Statements should include information on where data supporting the results reported in the article can be found including, where applicable, hyperlinks to publicly archived datasets analyzed or generated during the study. Where research data are not publicly available, this must be stated in the manuscript along with any conditions for accessing the data. Data Availability Statements must take one of the following forms (or a combination of more than one if required for multiple types of research data):

  • The datasets generated during and/or analyzed during the current study are available in the [NAME] repository, [PERSISTENT WEB LINK TO DATASETS]
  • The datasets generated during and/or analyzed during the current study are not publicly available due [REASON WHY DATA ARE NOT PUBLIC] but are available from the corresponding author on reasonable request. 
  • The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
  • Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. 
  • All data generated or analyzed during this study are included in this published article [and its supplementary information files].
  • The data that support the findings of this study are available from [third party name] but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of [third party name]. ​​


Emergency and Critical Care Medicine expects that each person listed as an author has participated sufficiently in the intellectual content, the analysis of data, and/or the writing of the manuscript to take public responsibility for it. Each author must have reviewed the manuscript, believes it represents valid work, and approves it for submission.

Moreover, should the Editorial team request the data upon which the manuscript is based, the authors shall produce it. Each author's specific contributions to the work should be indicated. For example, the areas of participation might include:

  • Participated in research design
  • Participated in the writing of the paper
  • Participated in the performance of the research
  • Contributed new reagents or analytic tools
  • Participated in data analysis

An author may list more than one contribution, and more than one author may have contributed to the same aspect of the work. Any change in authorship/contributions after submission must be approved in writing by all authors and submitted to the Editorial Office for final consideration.

English Language Assistance

Appropriate use of the English language is a requirement for publication in Journal name. Authors who have difficulty in writing in English who submit manuscripts to international journals often receive negative comments from referees or editors about the English-language usage in their manuscripts, and these challenges can contribute to a decision to reject a paper. To help reduce the possibility of such problems, we strongly encourage such authors consider using Wolters Kluwer Author Services**.

Wolters Kluwer Author Services​

Wolters Kluwer, in partnership with Editage, offers a unique range of editorial services to help you prepare a submission-ready manuscript. For more information regarding Wolters Kluwer Author Services, please visit http://wkauthorservices.editage.com.

**Note that the use of such a service is at the author's own expense and risk, and does not guarantee that the article will be accepted.

Reporting of Randomized Clinical Trials

Registration of Clinical Trials is an essential requirement for publication of clinical trials in Emergency and Critical Care Medicine. On the title page of your manuscript, provide the name of the trial registry and the registration number/identifier of the trial.

Acceptable web-based clinical trial registries include the following:

Reports of randomized clinical trials should follow the recommendations given in the Consolidated Standards of Reported Trials (CONSORT) statement. In brief, this statement comprises a checklist and flow diagram to help improve the quality of reports of randomized controlled trials and offers a standard way for researchers to report trials.

Optional Reporting Guidelines

The following resources may be helpful to authors:

  • PRISMA  –Preferred Reporting Items for Systematic Reviews and Meta-Analyses 
  • STROBE  - Strengthening the Reporting of Observational studies in Epidemiology 
  • CARE  - Strengthening the reporting of Clinical Case Report  

For further information regarding reporting guidelines, authors should consult the EQUATOR Network web site (http://www.equator-network.org ), which maintains a useful, up-to-date list of guidelines as they are published, with links to articles and checklists.​

Qualitative Research

Qualitative research provides in-depth insights about people's values, attitudes, beliefs, and experiences. Qualitative methodology informs approaches to data collection and analysis, and includes grounded theory, ethnography, and phenomenology. Open-ended interviews and focus groups are commonly used to collect data. Authors are advised to follow the COREQ guidelines for reporting primary qualitative research. Please visit: http://intqhc.oxfordjournals.org/content/19/6/349.full.pdf

Systematic review and/or synthesis of primary qualitative studies can provide a broader understanding of people's perspectives across different healthcare contexts. Methodologies for synthesis of qualitative research include thematic synthesis, meta-ethnography and critical interpretive synthesis. Authors can refer to the ENTREQ statement at

Financial Support and Competing Interests

A financial disclosure section is part of the submission process and must be completed by each author at first revision. This information is for review by the Editors but will be published if relevant to the content of the accepted manuscript.

The primary purpose of the disclosure section is to determine whether authors have received any commercial financial support that could create a conflict of interest. In addition to monetary interests, a potential for conflict of interest can exist whether or not an individual believes that a relationship (such as dual commitments, competing interests, or competing loyalties) affects his or her scientific judgment. Please review ICMJE Uniform Requirements for Manuscripts Submitted to Biomedical Journals at the following link http://www.icmje.org/conflicts-of-interest.


When reporting studies on human beings, author should indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional or regional) and with the Helsinki Declaration. For prospective studies involving human participants, authors are expected to mention about approval of regional/national/institutional or independent ethics committee or review board, obtaining informed consent from adult research participants and obtaining assent for children aged over 7 years participating in the trial. The age beyond which assent would be required could vary as per regional and/or national guidelines. Ensure confidentiality of subjects by desisting from mentioning participants' names, initials or hospital numbers, especially in illustrative material. When reporting experiments on animals, indicate whether the institution's or a national research council's guide for, or any national law on the care and use of laboratory animals was followed.

Evidence for approval by a local ethics committee (for both human as well as animal studies) must be supplied by the authors on demand. Animal experimental procedures should be as humane as possible and the details of anesthetics and analgesics used should be clearly stated. The ethical standards of experiments must be in accordance with the guidelines provided by the CPCSEA and World Medical Association Declaration of Helsinki on Ethical Principles for Medical Research Involving Humans for studies involving experimental animals and human beings, respectively. The journal will not consider any paper which is ethically unacceptable. A statement on ethics committee permission and ethical practices must be included in all r​esearch articles under the “Methods" section. 

Protection of Patients' Rights to Privacy

Identifying information should not be published in written descriptions, photographs, sonograms, CT scans, etc., and pedigrees unless the information is essential for scientific purposes and the patient (or parent or guardian, wherever applicable) gives written informed consent for publication. Authors should remove patients' names from figures unless they have obtained written informed consent from the patients. The journal abides by ICMJE guidelines: (1) Authors, not the journals nor the publisher, need to have the patient consent form before the publication related to patient privacy and have the form properly archived by the author. (2) If the publication includes some facial images that make the patients identifiable, a statement about the patient's consent needs to be present in the manuscript.

Peer Review

Emergency and Critical Care Medicine operates a single-blind external peer review process, wherein the names of the reviewers are hidden from the author. A brief introduction on the peer review process of the journal:

On submission, editors review all submitted manuscripts initially for suitability for formal review. Manuscripts with insufficient originality, serious scientific or technical flaws or lack of a significant message are rejected before proceeding for formal peer-review. Manuscripts that are unlikely to be of interest to the readers of the journal are also liable to be rejected at this stage.

Manuscripts that are found suitable for the potential publication of the journal are sent to a minimum of two independent expert reviewers to assess the scientific quality of the manuscript. Authors submitting manuscripts to Emergency and Critical Care Medicine may propose suitable reviewers or oppose reviewers who may have competing interests. The proposed reviewers should not be affiliated with the same institutes as the contributor(s). However, the selection of these reviewers is at the sole discretion of the editor, who selects reviewers to reflect relevant expertise, diversity, and geographical backgrounds.

Peer reviewers have access to the submitted manuscript and any appendices included by the authors. If the paper is a randomized controlled trial, peer reviewers will also have access to the trial protocol. Peer review assists editors in their decision on whether to publish an article and helps authors revise and improve their manuscripts. Peer reviewers make suggestions for improvements, critique the analysis, point out relevant published work which is not yet cited, and provide recommendations to the authors and the editors. At Emergency and Critical Care Medicine, reviewer comments are sent to the authors anonymously. Details of peer review including dates and peer review comments are not shared publicly. Reviewed articles are treated confidentially prior to their publication.

Based on the comments from the reviewers, the handling editor takes an acceptance decision on the manuscript and convey the comments and suggestions (acceptance/ rejection/ amendments in manuscript) to the corresponding author, who is requested to provide a point by point response to reviewers’ comments and submit a revised version of the manuscript. This process is repeated until reviewers and editors are satisfied with the manuscript. Manuscripts are accepted on the basis of quality, originality, significance, novelty and importance for the field.

Manuscripts received from Editorial Board Members will be screened by the Editor-in-Chief and sent to external peer reviewers. The Editorial Board Members who are authors will be excluded from publication decisions.

All special issue articles follow the same peer review process as above.


The journal accepts manuscripts that have been published on pre-print servers. However, the author(s) must declare that they have uploaded their manuscript on a pre-print server and provide its details viz., manuscript title, pre-print server name, doi, and link in the cover letter. In the event that the author(s) fails to declare the pre-print submissions and provide the necessary information, the manuscript will be rejected.

Types of Manuscripts Published

Type Text Word Guideline* Abstract Word Guideline Figure/Table Guideline Reference Guideline
Original ArticleNo less than 2,500 words, there is no explicit limit on the length of papers submitted, but authors are encouraged to be concise300 words max, structured into:
Background, Methods, Results, and Conclusion

Each table should be numbered and cited in sequence using Arabic numerals (i.e., Table 1, 2, 3, etc.). Titles for tables should appear above the table and be no longer than 15 words

Please note that it is the responsibility of the author(s) to obtain permission from the copyright holder(s) to reproduce figures or tables that have previously been published elsewhere.

Numbered consecutively, in square brackets, in the order in which they are cited in the text, and should be formatted in AMA style, more information on References Format.

Citations in the reference list should include all named authors, up to the first 6, before adding 'et al.'. Any in press articles cited within the references and necessary for the reviewers' assessment of the manuscript should be made available if requested by the editorial office.

ReviewSame as Original Article350 words unstructuredAs aboveAs above
Case Report800 – 2,000 words150 words, unstructuredAs aboveAs above
Meta-analysisN/A350 words max, structured into:
Background, Methods, Results, and Conclusion
As aboveAs above
500 – 2,000 wordsNo abstractAs aboveAs above
MethodologyNo less than 1,500 words300 words max, unstructured As aboveAs above
Perspective/ViewpointNo less than 150 wordsN/AAs aboveAs above
EditorialNo less than 800 wordsN/A As aboveAs above
N/ANo abstractAs aboveAs above
N/ANo abstractAs aboveAs above
CommunicationNo more than 5,000 wordsDepending on the content, either a structured abstract or unstructured abstractAs aboveAs above
Letter to the EditorNo more than 3,000 wordsNo abstract
As above
As above

​No less than 2,500  words
​As above
​As above
  • Original Article: Full-length reports of completed basic and experimental research, technical reports, or clinical and translational research. There is a minimum length of 2500 words, but shorter articles can also be considered, as long as these are fully completed studies. Articles have an abstract of maximum 300 words.
  • Review: Articles have a minimum length of 2500 words and an abstract of maximum 350 words. Review articles should not simply summarize information, but also discuss the importance and impact of the data providing a clear view on how these insights have transformed or will transform the emergency and critical care field. Authors of review articles are encouraged to include several figures and tables to summarize and visualize data.
  • Case Report: Reports of clinical cases that can be educational, describe a diagnostic or therapeutic dilemma, suggest an association or present an important adverse reaction. Authors should clearly describe the clinical relevance or implications of the case. All case report articles should indicate that informed consent to publish the information has been granted from the patients or their guardians. The title should include the words “case report”, and Keywords should include the words “case report” but not exceed 5.
  • Meta-analysis: Systematic, critical assessments of literature and data sources pertaining to clinical topics, emphasizing factors such as cause, diagnosis, prognosis, therapy, or prevention, and that includes a statistical technique for quantitatively combining the results of multiple studies that measure the same outcome into a single pooled or summary estimate.
  • Comment: Short, focused, opinion articles on any subject within the scope of the journal. These articles are usually related to contemporary issues, such as recent research findings, and are often written by opinion leaders.
  • Methodology: Articles presenting a new experimental method, test or procedure. The method described may be new, or may offer a better version of an existing method.
  • Perspective/Viewpoint: Perspective/Viewpoint may address virtually any important topic in medicine, public health, research, discovery, prevention, ethics, health policy, or health law and generally are not linked to a specific article. Viewpoints should be well focused, scholarly, and clearly presented but should not include the findings of new research or data that have not been previously published. Perspective/Viewpoint should have a minimum length of 150 words and be as current as possible.
  • Editorial: Editorials are invited articles to explain the importance of specific articles or to provide opinions on general concepts in practice, research or policy. Editorials have a minimum length of 800 words.
  • Image: Classic images displaying medical conditions that capture the sense of visual discovery and variety that physicians experience in clinical practice. To be considered for publication, images must be high resolution and high in quality.
  • Communication: These manuscripts describe an important issue in clinical medicine, public health, health policy, or medical research in a scholarly, thorough, well-referenced, systematic, and evidence-based manner or original studies or evaluations or unique, first-time reports of clinical case series.
  • Letter to the Editor: These can take three forms, a substantial re-analysis of a previously published article; a substantial response to such a re-analysis from the authors of the original publication; or an article that may not cover 'standard research' but that may be relevant to readers.
  • Consensus: a comprehensive analysis of a disease or condition, therapy, intervention, or health policy, often resulting from the work of a consensus conference or expert panel convened to offer recommendations or to set policy to improve health care.

Manuscript Preparation and Formating Instructions

Manuscripts must be written in clear, grammatical English (see English Language Assistance above). Manuscripts not conforming to Journal format will be returned to authors for modification. Please double space the entire main body document and number each page. Do not add line numbers as the system will generate those when the PDF is built.

Cover Letter (optional)

Cover letter should include the name(s) and contact information of the corresponding author(s). Include the title of the manuscript, describe the rationale behind the study and the major findings from the research. Also state other issues, including duplicate publication, conflicts of interest and ethical approval statements.

Title page, and abstract pages must be included in the main body file. Please do not upload separate copies of these documents.

Acceptable document file types for text and tables include .DOC and .DOCX; do not submit a PDF.

Page 1:
Title Page. The following elements are required for every submission:
Title. Include a descriptive title of the work; the title should not be a sentence. No proprietary or brand names for drugs or agents may be used in article titles.

Authors. The full first name, middle initials, and family name of each author, as well as the name(s) of the department(s) and institution(s) to which the work should be attributed.
Address for Correspondence. A current email and full mailing address for the corresponding author must be provided.
Clinical Trials (optional).  If clinical trials are involved, provide the name of the trial registry and the registration number/identifier of the trial.
Keywords. Include three to eight key words.

Page 2
Abstract. Where required, abstracts are limited to 300 words, which is included in the overall manuscript word count. The abstract for Overviews may be unstructured. The abstract for Articles and Short Reports should be structured into four paragraphs, labeled Background, Methods, Results, and Conclusion. They should briefly describe, respectively, the problem being addressed in the study, how the study was performed, the salient results, and what the authors conclude from the results.

Main Body:

Introduction. The introduction contains a statement of the purpose of the work, the problem that stimulated it, and a brief summary of relevant published investigations.

Materials and Methods. Avoid detailed description of previously published methods and cite the appropriate reference. Detailed methods may be provided as Supplemental Digital Content and will appear in the online version only.

Results. The results should be concise, avoiding redundant tables and figures illustrating the same data.

Discussion. This section should follow the results and is used to interpret results, with minimal recapitulation of findings.

Conflict of interest statement. Authors must state all possible conflicts of interest in the manuscript, including financial, consultant, institutional and other relationships that might lead to bias or a conflict of interest. If there is no conflict of interest, this should also be explicitly stated as none declared. Please include the phrase, "The authors declare no conflict of interest."

Author contributions. This section lists each author's specific contributions to the work. For example, the areas of participation might include:

  • Participated in research design
  • Participated in the writing of the paper
  • Participated in the performance of the research
  • Contributed new reagents or analytic tools
  • Participated in data analysis

An author may list more than one contribution, and more than one author may have contributed to the same aspect of the work. Any change in authorship/contributions after submission must be approved in writing by all authors and submitted to the Editorial Office for final consideration.

Funding. This section discloses the funding received for this work, especially details of funding from any of the following organizations: National Natural Science Foundation of China (NSFC), National Institutes of Health (NIH), Wellcome Trust, and Howard Hughes Medical Institute (HHMI), etc. If there is no funding, this should also be explicitly stated as "None".

Ethical approval of studies and informed consent. For all manuscripts reporting data from studies involving human participants or animals, formal review and approval, or formal review and waiver, by an appropriate institutional review board or ethics committee is required and should be described in the Methods section or in this section. For those investigators who do not have formal ethics review committees, the principles outlined in the Declaration of Helsinki should be followed. For investigations of humans, state in the Methods section the manner in which ​written informed consent was obtained from the study participants and whether participants received a stipend. Authors of research studies involving humans should not make independent determinations of exemption or exclusion of IRB or ethical review; they should cite the institutional or regulatory policy for that determination and indicate if the data are deidentified and publicly available or protected by prior consent or privacy safeguards. Editors may request that authors provide documentation of the formal review and recommendation from the institutional review board or ethics committee responsible for oversight of the study. If there is no Ethical Approval of Studies and Informed Consent, please indicate, "Not applicable – Not required for this study."

Acknowledgements. This section normally includes sources of research funds, the names of collaborators who are not listed as coauthors, or of any others who contributed to the manuscript. Where a medical writer or editorial assistant has been used to write or edit the article, the writer must be identified and named, together with the source of funding. If there is no acknowledgement, it should also be explicitly stated as “None".

Availability of Data and Materials(optional). This journal encourages and enables you to share data that supports your research publication where appropriate. Research data refers to the results of observations or experimentation that validate research findings. To facilitate reproducibility and data reuse, this journal also encourages you to share your software, code, models, algorithms, protocols, methods, and other useful materials related to the project.​

References. The journal uses American Medical Association (AMA 11th edition) style. References should begin on a separate page and numbered in the order in which they are cited in the text, where they are designated by superscript numbers placed outside periods and commas, and inside colons and semicolons. Only published works and manuscripts that have been accepted for publication should be listed in the References. Manuscripts in preparation, unpublished observations, and personal communications should be referred to in parentheses in the text. Completed manuscripts submitted for publication may be cited as footnotes to the text (see above, Footnotes). If these are subsequently accepted, the author may transfer them to the reference section in galley proof.

References Format. No more than six authors should be listed. If there are seven or more, only the first three followed by “et al.” should be included. Titles of journal articles must be included, and abbreviation of journal names should conform to Index Medicus style.

For information on AMA style, please visit http://www.amamanualofstyle.com.

Examples of References style:

No more than six authors:

Ahmed KA, Xiang J. Mechanisms of cellular communication through intercellular protein transfer. J Cell Mol Med. 2011;15(7):1458−1473. doi:10.1111/j.1582-4934.2010.01008.x

Youngster I, Russell GH, Pindar C, Ziv-Baran T, Sauk J, Hohmann EL. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficileinfection. JAMA. 2014;312(17):1772−1778. doi:10.1001/jama.2014.13875

More than six authors:

VanderPluym JH, Halker Singh RB, Urtecho M, et al. Acute treatments for episodic migraine in adults: a systematic review and meta-analysis. JAMA. 2021;325(23):2357−2369. doi:10.1001/jama.2021.7939

Organization as author:

Chinese Society of Emergency Medicine. Expert Group of Chinese Emergency Medicine Expert Consensus on diagnosis and treatment of sepsis complicated with disseminated intravascular coagulation. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29(7):577−​580. doi:10.3760/cma.j.issn.2095-4352.2017.07.001​

British Transplant Society. ​Donation after Circulatory Death. Accessed August 1, 2013.​ http://www.bts.org.uk/Documents/Guidelines

Articles viewed online, without DOI:

Wong FS, Campbell DR, Becker BE. Head injury and video games. Accessed August 19, 2019. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1010657/​​​

Tables: Photographs of tables are not acceptable. Type each table, double-spaced throughout (including column headings, footnotes, and data), on a separate page. Tables may be included as part of the Main Body file and placed after the References section. Number the tables in sequence in Arabic numerals and supply a concise, informative title for each one. Each column in the tables should carry a concise heading describing the data in the column. Use lowercase superscript letters to designate footnotes, and type the footnotes below the tables to which they refer. Tables are cited in the text in numerical order. Each table should be able to be understood without consulting the text.

Like text, tables should be prepared using a standard word-processing program and may be included within the main body text document, or uploaded separately. Do not upload table files more than once (that is, in the main document and in separate files).

Acceptable document file types for tables include .DOC and .DOCX; do not submit PDF, XLS or XLSX type files.

Figures and Legends: Do not embed figures into the main body file. Figures should be uploaded in the highest resolution available. Legends should be supplied for all figures. They are numbered to correspond with the figures and typed double-spaced on a separate page. Figure legends for any supplemental figures being submitted are to be provided separately; see section, Supplemental Digital Content (SDC).

Acceptable figure file formats​

  • All final digital figures for accepted manuscripts must be submitted in EPS, TIFF, JPG. PowerPoint PPT format is permitted when the image resolution is very high.
  • Each figure must be uploaded as a separate file.
  • Histology figures must be in color.
  • Monochrome images (such as line graphs) should be prepared at a resolution of 1200 DPI.
  • Halftones images (black/white or color) should be prepared at a resolution of 300 DPI.
  • Combination halftones (images containing both pictures and text labeling) should be prepared at 600 DPI.
  • Color images must be saved as “CMYK". Images saved as “RGB" are not acceptable for printing.
  • Your manuscript may be returned to you for correction if the images are of insufficient quality.
  • Artwork submitted to the Journal will be checked for quality. Authors submitting a revised paper will have the opportunity to check the quality of their images and make the necessary changes. This step is required for all revisions.

Supplemental Digital Content (SDC): Authors may submit Supplemental Digital Content to supplement the information provided in the manuscript. It is preferable to include all significant figures and tables in the manuscript, since there is not a limit on the number of items in this online journal. Nonetheless, SDC may include the following types of content: text, tables, figures, references peripheral to information provided as SDC, audio, and video. SDC should be consecutively cited in the Main Body text of the submitted manuscript. SDC files will be available via URL(s) placed at the citation points within the article and are not copyedited by the publisher. Note that Journal policies for manuscript submission relating to peer review, patient anonymity, ethics, financial disclosure, copyright, and permissions also apply to SDC. Authors should mask patients' eyes and remove patients' names from supplemental digital content unless they obtain written consent from the patients and submit them as supplemental files at the time of the manuscript submission.

Format, File Type and Size Requirements: SDC must be provided in one Word or PowerPoint file. Each SDC in the file should have a visual header in the following name format (e.g., “SDC, Figure 1"; “SDC, Materials and Methods") and a corresponding citation must appear in the Main Body text. Note that SDC is numbered separately from non-SDC material. If providing SDC figure(s), a figure legend should be included on the figure itself. When uploading SDC select “Supplemental Digital Content" as the file designation. For audio and video files, also include the author name, videographer, participants, length (minutes), and size (MB). Video files should be formatted with a 320x240 pixel minimum screen size. For each submission, the SDC file cannot exceed a total size of 10 MB.


New Submissions

Once the manuscript has been created, visit the submission site at https://www.editorialmanager.com/eccm/ to upload the manuscript. Once the manuscript has been vetted for compliance to the Journal's requirements, a manuscript number will be assigned to the submission. Failure to adhere to these guidelines will result in your manuscript being returned to you for correction. Faxed, scanned or emailed copies of manuscripts will not be accepted.

Revised Submissions

All revised submissions require a point-by-point response to the reviewers' comments. Please upload this document as file type Response to Reviewers.

Changes made in the revised manuscript should be indicated using highlighted, bold or underlined text. Upload both a Marked and a Clean version of the revised manuscript. File types are provided for both versions.

A requirement of all revisions is the artwork quality check as described above (see Figures and Legends).

Revised manuscripts should be submitted within the deadline specified in the decision letter. Please contact us for an extension of the due date if it is not possible to submit the revision within that period, or should you desire to withdraw the manuscript from further consideration.

Revisions should adhere to original specifications for the submission type. Sometimes changes made in response to the decision/critiques may bring the revised manuscript out of compliance (e.g., over the word count and/or table/figure limit) with original specifications. This may be allowed by the Editor, but must be noted in the point-by-point response.

Mandatory Author Forms

Upon first revision, authors will be required to complete a Copyright Transfer Agreement (CTA) form​. CTA forms are required of every author listed on the submission. Please ensure each author's email address is properly listed on the footnotes page of your manuscript to avoid delays in reaching authors. Manuscripts will not pass to production without completed forms. CTA forms are available from the site https://edmgr.ovid.com/eccm/accounts/ECCM_Copyright_form_Template_TG.pdf.

Submitting Invited Videos

Authors may want or be invited to submit videos to the Journal's website. The videos will serve to emphasize key aspects of the research findings reported in their soon to be published manuscript. Please visit Stand Alone Video Format Requirements http://links.lww.com/ES/A159 to download full specifications and instructions for preparing these invited videos.

Post Acceptance ​

Page Proofs

The publisher's Journal Production Editor will contact you when page proofs are ready for your review. The figures included on author's proofs are high resolution. Please inform the Journal Production Editor immediately if you have any questions concerning the quality of the figures on the proofs. For information regarding proofs, or the status of publication of your accepted manuscript, please the editorial office by E-mail: [email protected]

Changes in Corresponding Author's Contact Information

Please give all new information, including email address, to the editorial office and to the publisher. If the Journal is unsuccessful in contacting the corresponding author, the author will not receive proofs for approval, and the manuscript may not be published.

Changes at Proofs

It is expected that the final manuscript sent to the Editor is indeed the final version, so few changes should be required at proof stage.


Shandong University is the owner of all copyrights to any articles published in the journal. 

Open Access

Every peer-reviewed research article appearing in this journal will be published open access. This means that the article is universally and freely accessible via the internet in perpetuity, in an easily readable format immediately after publication. The journal does not charge for submission, processing or publication of manuscripts and even for color reproduction of photographs. Shandong University will pay to make the article open access.

Creative Commons licenses

Open access articles will be freely available to read, download and share from the time of publication. Articles are published under the terms of the Creative Commons License Attribution-Non Commercial No. Derivative 4.0 which allows readers to disseminate and reuse the article, as well as share and reuse of the scientific material. It does not permit commercial exploitation or the creation of derivative works without specific permission. To view a copy of this license visit

Editorial Office Contacts

The Editorial Office is pleased to answer any questions you may have about preparing your manuscript in accordance with our guidelines.

Email: [email protected]

Submit a manuscript: https://www.editorialmanager.com/eccm/