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Does daily caffeine intake increase the risk of anxiety?

Nymberg, Jerome MD; Vang, Ying MD; Clough, Nicholas MD; Masters, Cheryl PhD

doi: 10.1097/01.EBP.0000541940.88000.28

EVIDENCE-BASED ANSWER Caffeine increases self-rated anxiety more than placebo, but the dose-response relationship is inconsistent (SOR: B, 2 small RCTs). This effect may be exclusive to men (SOR: C, small RCT). Patients with generalized anxiety disorder are more sensitive to the anxiogenic effects of caffeine than patients with panic disorder or no psychiatric illness (SOR: B, small RCT).

Cabarrus FMRP Concord, NC

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