HelpDesk AnswersIn outpatients dependent on benzodiazepines, what medications can increase discontinuation rates?Bradley, Juliet MD; Rodriguez, Vimarie MD Author Information Cook County-Loyola-Provident FMRP Chicago, IL Evidence-Based Practice: April 2013 - Volume 16 - Issue 4 - p 10-11 doi: 10.1097/01.EBP.0000540367.62220.c6 Buy Metrics Abstract Evidence-Based Answer The addition of imipramine or melatonin to a gradual benzodiazepine taper results in higher discontinuation rates than use of a placebo. Carbamazepine also helps with a benzodiazepine taper, but any eventual discontinuation is not sustained (SOR: B, meta-analysis of RCTs with heterogeneity and an individual RCT). © Copyright 2013 Family Physicians Inquiries Network, Inc.
