Ménière’s is a multifactorial disease, exhibiting symptoms of vertigo, aural fullness, tinnitus, and hearing loss. Currently its etiology and health impacts are poorly understood. A greater understanding of this condition is required to delineate pathological pathways, and improve treatment for those with Ménière’s. Using data from the new UK Biobank, this study investigated demographic factors and other health conditions associated with Ménière’s disease in the largest study to date. The findings indicate that the autonomic nervous system has a role in Ménière’s etiology and suggests an intricate interplay between the autonomic and immune systems may contribute to the pathological pathway.