ReviewImproving Clinical Outcomes in Cochlear Implantation Using Glucocorticoid Therapy A ReviewCortés Fuentes, Ignacio A.1,2; Videhult Pierre, Pernilla3; Engmér Berglin, Cecilia2Author Information 1Department of Otorhinolaryngology, Hospital San Juan de Dios, University of Chile, Santiago, Chile 2Department of Clinical Science, Intervention and Technology, Division of Ear, Nose and Throat Diseases, Karolinska Institutet, Stockholm, Sweden 3Department of Clinical Science, Intervention and Technology, Division of Audiology, Karolinska Institutet, Huddinge, Sweden. Received October 8, 2018; accepted March 14, 2019. Address for correspondence: Cecilia Engmér Berglin, Department of Otorhinolaryngology, B53, Karolinska University Hospital, 141 86 Stockholm, Sweden. E-mail: firstname.lastname@example.org Online date: April 30, 2019 Ear and Hearing: January/February 2020 - Volume 41 - Issue 1 - p 17-24 doi: 10.1097/AUD.0000000000000740 Buy Metrics Abstract Cochlear implant surgery is a successful procedure for auditory rehabilitation of patients with severe to profound hearing loss. However, cochlear implantation may lead to damage to the inner ear, which decreases residual hearing and alters vestibular function. It is now of increasing interest to preserve residual hearing during this surgery because this is related to better speech, music perception, and hearing in complex listening environments. Thus, different efforts have been tried to reduce cochlear implantation-related injury, including periprocedural glucocorticoids because of their anti-inflammatory properties. Different routes of administration have been tried to deliver glucocorticoids. However, several drawbacks still remain, including their systemic side effects, unknown pharmacokinetic profiles, and complex delivery methods. In the present review, we discuss the role of periprocedural glucocorticoid therapy to decrease cochlear implantation-related injury, thus preserving inner ear function after surgery. Moreover, we highlight the pharmacokinetic evidence and clinical outcomes which would sustain further interventions. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.