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The impact of butorphanol in rat temporomandibular joint inflammation

Al-Kibsi, Taghreed A.M.a; Tawfik, Mona K.b; El-Sholkamy, Mohammed A.c; Ghanem, Walid A.c; Elsharrawy, Eman A.c

Egyptian Journal of Oral & Maxillofacial Surgery: October 2017 - Volume 8 - Issue 3 - p 57–61
doi: 10.1097/01.OMX.0000525212.77019

Objective The objective of the present study was to evaluate the anti-inflammatory effect of butorphanol in formalin-induced temporomandibular joint (TMJ) inflammation in rats.

Materials and methods A total of 30 adult male Wistar rats were randomly divided into three groups of 10 rats each – group 1, the saline control group: rats were subjected to TMJ injection of saline; group 2, the formalin control group: rats were subjected to TMJ injection of formalin and did not receive any treatment; group 3, the butorphanol-treated group: rats received TMJ injection of 0.4 mg/kg butorphanol 30 min after TMJ injection of formalin.

Results TMJ injection of 1.5% formalin-induced inflammation in the form of significant (P<0.5) elevation of C-reactive protein and destruction of TMJ structure compared with the normal control group. Treatment with butorphanol decreased (P<0.05) the severity of formalin-induced TMJ inflammation and improved the histopathological TMJ structure.

Conclusion The present results support that butorphanol tartrate has anti-inflammatory properties.

aDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sana’a University, Yemen

bDepartment of Pharmacology, Faculty of Medicine

cDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Suez Canal University, Suez Canal, Ismailia, Egypt

Correspondence to Taghreed A.M. Al-Kibsi, MSc, Faculty of Dentistry, Sana’a University, Yamen, Egypt Tel: +20 112 761 0387; e-mail:

Received July 1, 2017

Accepted July 15, 2017

© 2017 Egyptian Associations of Oral and Maxillofacial Surgery
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