The objective of the present study was to evaluate the anti-inflammatory effect of butorphanol in formalin-induced temporomandibular joint (TMJ) inflammation in rats.
A total of 30 adult male Wistar rats were randomly divided into three groups of 10 rats each – group 1, the saline control group: rats were subjected to TMJ injection of saline; group 2, the formalin control group: rats were subjected to TMJ injection of formalin and did not receive any treatment; group 3, the butorphanol-treated group: rats received TMJ injection of 0.4 mg/kg butorphanol 30 min after TMJ injection of formalin.
TMJ injection of 1.5% formalin-induced inflammation in the form of significant (P<0.5) elevation of C-reactive protein and destruction of TMJ structure compared with the normal control group. Treatment with butorphanol decreased (P<0.05) the severity of formalin-induced TMJ inflammation and improved the histopathological TMJ structure.
The present results support that butorphanol tartrate has anti-inflammatory properties.
aDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sana’a University, Yemen
bDepartment of Pharmacology, Faculty of Medicine
cDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Suez Canal University, Suez Canal, Ismailia, Egypt
Correspondence to Taghreed A.M. Al-Kibsi, MSc, Faculty of Dentistry, Sana’a University, Yamen, Egypt Tel: +20 112 761 0387; e-mail: firstname.lastname@example.org
Received July 1, 2017
Accepted July 15, 2017