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Efficacy of topical melatonin hormone on implant osseointegration

Al-Sehimy, Mohammada; Al-Dharrab, Aymanb; Jan, Ahmada

Egyptian Journal of Oral & Maxillofacial Surgery: October 2017 - Volume 8 - Issue 3 - p 62–69
doi: 10.1097/01.OMX.0000525217.51469

Objective The aim of this study was to assess the effect of melatonin hormone on osseointegration of immediately loaded dental implants. Bone quality and quantity around an immediately loaded dental implant through evaluating the changes in the peri-implant bone density and height using digital radiograph were performed.

Patients and methods All patients received two dental implants, 13 mm length and 3.7 mm width, attached to a ball-attachment abutment to retain a mandibular over denture. Implants were placed at the area of the mandibular canines and were immediately loaded. The right implants only for all patients were subjected to melatonin application throughout the study period of the whole 6 months. The left implants were left as a control side.

Results The melatonin side showed a statistically significantly higher mean bone density than the control side. The melatonin side showed a statistically significantly higher mean percentage increase in implant stability quotient value than the control side through all periods.

Conclusion The present investigation demonstrated that a 6-month melatonin application significantly positively influenced implant stability and bone density around dental implants in all subjects. The exact mechanism of the melatonin on bone metabolism needs further histopathological and bone morphmetric studies in animals.

Departments of aOral and Maxillofacial Surgery, Faculty of Dentistry

bRemovable Prosthodontics, King Abdulaziz University, Jeddah, Kingdome of Saudi Arabia

Correspondence to Mohammad Al-Sehimy, PhD, Professor of Oral & Maxillofacial surgery, King Abdulaziz University, Jeddah 21589, PO Box 80209, Saudi Arabia Tel: +966 9666403443; fax: +966 9666403316; email

Received July 4, 2017

Accepted July 18, 2017

© 2017 Egyptian Associations of Oral and Maxillofacial Surgery
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