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Alveolar cleft repair using autogenous bone marrow-derived mesenchymal stem cells

Khalifa, Mahmoud E.; Nowair, Ibrahim M.

Egyptian Journal of Oral & Maxillofacial Surgery: May 2017 - Volume 8 - Issue 2 - p 46–51
doi: 10.1097/

Background The bone graft for the alveolar cleft has been accepted as one of the essential treatments for cleft lip and palate patients. Recently, tissue engineering has become available as a regenerative treatment for bone defects; however, little has been reported on application of tissue engineering for regeneration of cleft defect tissues. Mesenchymal-derived stem cells were applied to different kinds of bone substitute in an attempt to overcome the drawbacks of bone grafting.

Materials and methods Eight patients with alveolar cleft were included in this study; the cleft repair was done using bone marrow-derived stem cell loaded on NanoBone scaffold. All patients were followed up clinically and radiographically for 6 months postopertively.

Results The successful healing left no fistula or oronasal communication. Uneventful wound healing was seen during follow-up. All patients gained closure of the alveolar arch and stabilization of the teeth adjacent to the cleft. The radio-opacity in serial computed tomography slicing the middle level of the alveolar cleft in the grafted region increased gradually over the time.

Conclusion Tissue-engineered bone from mesenchymal stem cells may provide an acceptable alternative especially in the case of limited autograft availability or donor-site morbidity.

Department of Oral and Maxillofacial, Faculty of Dentistry, Tanta University, Tanta, Egypt

Correspondence to Mahmoud E. Khalifa, BSc, MSc, DDS oral and Maxillofacial surgery, Department of Oral and Maxillofacial, Faculty of Dentistry, Tanta University, Tanta, Egypt Tel: +20 100 782 6337; fax: + 20 040 334 4173; e-mail:

Received February 8, 2017

Accepted March 4, 2017

© 2017 Egyptian Associations of Oral and Maxillofacial Surgery
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