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Assessment of the effect of gap arthroplasty on serum interleukin-1β in patients with temporomandibular joint bony ankylosis

Dehis, M.; Ahmed, Mamdouh S.; El Khateeb, E.; Kamal, A.; Osama, M.

Egyptian Journal of Oral & Maxillofacial Surgery: January 2016 - Volume 7 - Issue 1 - p 2–8
doi: 10.1097/01.OMX.0000473757.14356.7b
ORIGINAL ARTICLES
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Objectives The aim of this study was to assess the effect of gap arthroplasty on immunocompetence of patients with temporomandibular joint bony ankylosis (TMJBA) in terms of interleukin-1β (IL-1β).

Patients and methods Twenty-six patients were recruited from among those attending the outpatient clinic, Department of Oral and Maxillofacial Surgery, Faculty of Oral and Dental Medicine, Cairo University. They were classified into two groups: group I included 10 patients with TMJBA (surgical group) and group II included 16 healthy participants as volunteers related to or neighbors of the selected patients and represented the control group. Gap arthroplasty was performed on group I either unilaterally or bilaterally under general anesthesia at the Dental Educational Hospital, Cairo University, Egypt. Assessment of the effect of gap arthroplasty on immunocompetence was performed utilizing the enzyme-linked immunosorbent assay technique to attune serum IL-1β. Malnutrition was assessed through anthropometric measurements using BMI.

Results A significant increase in the level of IL-1β was detected in the surgical group preoperatively compared with the control group. IL-1β showed a significant increase at all intervals postoperatively. IL-1β began to decrease at 2 weeks postoperatively, but still did not reach the preoperative level.

Conclusion The present study showed that patients with TMJBA have a significantly high level of serum IL-1β preoperatively. Gap arthroplasty and its relevant jaw mobilization have a direct effect on immunocompetence. This was apparent from the increased level of IL-1β postoperatively.

aDepartment of Oral & Maxillofacial Surgery, Faculty of Oral & Dental Medicine

bDepartment of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo

cDepartment of Oral & Maxillofacial Surgery, College of Oral & Dental Surgery, Misr University for Science & Technology, Giza

dMinistry of Health, Mansoura, Egypt

Correspondence to Prof., M. Dehis, Department of Oral and Maxillofacial Surgery, Faculty of Oral and Dental Surgery, Cairo University, Cairo, Egypt Tel: +20 245 43572, +20 100 660 7976; e-mail: mesd47@gmail.com

Received September 12, 2015

Accepted September 29, 2015

© 2016 Egyptian Associations of Oral and Maxillofacial Surgery
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