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Clinical and radiographic evaluation of nanocrystalline hydroxyapatite bone graft in treatment of peri-implant defects in diabetic patients: a randomized, double-blind prospective cohort study

Elsayed, Shadia A.a; Attia, Mai SH.b; Gawish, Abeer S.c,d

Egyptian Journal of Oral and Maxillofacial Surgery: May 2014 - Volume 5 - Issue 2 - p 33–38
doi: 10.1097/01.OMX.0000444061.56326.e8
Clinical Papers

Objectives The aim of the present study was to evaluate the 9-month results obtained following treatment of peri-implant defects in diabetic patients using either a nanocrystalline hydroxyapatite (NHA) or hydroxyapatite (HA).

Patients and methods Fifteen type II diabetic patients suffering from moderate peri-implantitis (n=20, intrabony defects) were randomly treated with access flap surgery and the application of HA or with access flap surgery and the application of NHA. Clinical and radiographic parameters were recorded at baseline and after 6 and 9 months for the studied groups.

Results Both groups revealed clinical improvement in mean probing depth reductions (HA: 7.0±1.6 9–4.7±1.05 mm; NHA: 7.88±1.36–3.44±0.52 mm) and increase in mean bone density (HA: 47.39±4.9–54.84±2.98; NHA: 49.26±7.38–66.60±4.24). These clinical and radiographic improvements seemed to be better in the NHA group than in the HA group at the end of the study period.

Conclusion Within the limits of the present investigation, it can be concluded that both treatment modalities have shown predictable results over the 9-month study period; however, the application of NHA may result in more clinical and radiographic improvement of healing outcomes.

Departments of aOral and Maxillofacial Surgery

bOral Medicine and Periodontology

cFaculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt

dDepartment of Oral Medicine and Periodontology, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia

Correspondence to Shadia A. Elsayed, PhD, Departments of Oral and Maxillofacial Surgery, Al-Azhar University, Cairo, Egypt Tel: +002 01121281982; fax: +00224051396; e-mail:

Received January 14, 2014

Accepted February 11, 2014

© 2014 Egyptian Associations of Oral and Maxillofacial Surgery