A 17-year-old adolescent with acute nephrotoxicity had CYP3A4-5, CYP2C19, and ABCB1 genotyping performed to understand a suspected drug interaction between tacrolimus and omeprazole. The determinant role of individual pharmacogenetic profile in the occurrence of tacrolimus nephrotoxicity is presented and discussed.
*AP-HP, Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré
†INSERM, Clinical Investigation Center CIC9202
‡AP-HP, Department of Pediatric Nephrology, Hôpital Robert Debré
§AP-HP, Department of Pharmacy, Hôpital Robert Debré
¶Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
Correspondence: Wei Zhao, PharmD, PhD, Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, 48 Boulevard Sérurier, 75935 Paris Cedex 19, France (e-mail: firstname.lastname@example.org).
This work was supported by Global Research in Paediatrics – Network of Excellence (GRIP, EU-funded FP7 project, Grant Agreement number 261060).
The authors declare no conflict of interest.
Received August 22, 2012
Accepted August 29, 2012