Original Article: PDF OnlyMonitoring Pediatric Serum Theophylline, Phenobarbital, and Phenytoin with the IL Multistat III®Iosefsohn, Mariet*; Hicks, Jocelyn M.***Author Information *Department of Clinical Laboratories, Children's Hospital National Medical Center; and **Department of Child Health and Development and Pathology, George Washington University School of Medicine, Washington, D.C. Therapeutic Drug Monitoring: Volume 2 - Issue 3 - p 249-254 Buy Abstract Summary We compared results of theophylline, phenobarbital, and phenytoin assays by the EMIT® method using the IL Multistat III® Micro Centrifugal Analyzer with results by the EMIT semiautomated procedure on a Beckman 25 spectrophotometer equipped with a semiautomated pipettor-dilutor and a model 2400 automatic timer/printer. We assessed linearity, precision, specificity, and correlation with other methods. The IL MCA III is precise, easy to use, and suitable for routine use in a pediatric laboratory. Only 3 μl of serum is used for each drug analysis, and 17 results can be obtained in 8 min. Reagent costs can be reduced fourfold. © Lippincott-Raven Publishers.