What Is the Therapeutic Reference Range for Levetiracetam? Grand Round/A Case Study : Therapeutic Drug Monitoring

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What Is the Therapeutic Reference Range for Levetiracetam? Grand Round/A Case Study

Couderc, Sylvain PharmD*; Chouchane, Mondher MD†; Saint-Marcoux, Franck PharmD, PhD*

Author Information

*Department of Pharmacology and Toxicology, CHU Limoges, Limoges; and

†Department of Neuropediatrics, CHU Dijon, Dijon, France.

Correspondence: Couderc Sylvain, Centre de Biologie et de Recherche en Santé, CHU Dupuytren, 22 av. Martin Luther King, 87000 Limoges, France (e-mail: [email protected]).

The authors declare no conflict of interest.

Therapeutic Drug Monitoring 44(3):p 363-365, June 2022. | DOI: 10.1097/FTD.0000000000000972

Abstract

The Therapeutic Drug Monitoring guidelines of Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie had proposed a therapeutic reference range of 10–40 mg/L for levetiracetam in 2011. In the first version of the 2017 update, it was changed to 20–40 mg/L; however, 5 months later, in an erratum version, it was changed back to 10–40 mg/L. In this study, the authors agree with the range to 10–40 mg/L but discuss to what extent a wider interval may be proposed for certain patients.

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