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Therapeutic Drug Monitoring of Everolimus in Oncology

Evidences and Perspectives

Falkowski, Sabrina MD, PhD*; Woillard, Jean-Baptiste PharmD, PhD†,‡,§

doi: 10.1097/FTD.0000000000000628
Review Article
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Abstract: Everolimus is a mammalian target of rapamycin (m-TOR) inhibitor that has been approved for the treatment of hormone receptor-positive advanced breast cancer, metastatic renal cancer, and neuroendocrine tumors. Although therapeutic drug monitoring (TDM) of everolimus is well established in the transplantation field, it is not currently performed in oncology. The last consensus conference about the TDM of everolimus states that for the use of everolimus in oncology, “further studies are required to determine the clinical utility of TDM for everolimus in oncology settings.” In this review, the authors will discuss the current evidences and perspectives, based on observational studies available, in favor of the TDM of everolimus in oncology focusing on (1) the management of everolimus in routine practice, (2) the prerequisites for TDM of everolimus in oncology, (3) the pharmacodynamics (including a description of the biomarker of resistance and mutations in m-TOR), and (4) a general outlook.

*Department of Oncology, Clinique Chenieux;

Department of Pharmacology and Toxicology, CHU Limoges;

University of Limoges; and

§INSERM, IPPRITT, UMR1248, Limoges, France.

Correspondence: Jean-Baptiste Woillard, PharmD, PhD, Department of Pharmacology-Toxicology, CBRS, Limoges University Hospital, 2 Avenue Martin Luther King, 87042 Limoges Cedex, France (e-mail: jean-baptiste.woillard@unilim.fr).

The authors declare no conflict of interest.

Received October 24, 2018

Accepted January 07, 2019

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