Grand RoundTherapeutic Drug Monitoring of Clomipramine and Amitriptyline in a Depressed Patient With Upper Digestive Tract ResectionCouturier, Pierre-Louis MD*; Zahr, Noël PharmD, PhD†; Goldwirt, Lauriane PharmD†; Warot, Dominique MD, PhD†; Allilaire, Jean-François MD*; Lambrey, Simon MD, PhD* Author Information From the *Service de Psychiatrie Adulte; and †Service de Pharmacologie, AP-HP, Hôpital Pitié Salpêtrière, Paris, France. Received for publication March 7, 2011; accepted May 25, 2011. Correspondence: Noël Zahr Pharm D, PhD, Service de Pharmacologie, Groupe Hospitalier Pitié-Salpêtrière, 75651 Paris Cedex 13, France (e-mail: [email protected]). Therapeutic Drug Monitoring: August 2011 - Volume 33 - Issue 4 - p 467-468 doi: 10.1097/FTD.0b013e318226396a Buy Metrics Abstract We describe a 55-year-old woman with extensive digestive resection and recurrent depressive disorder resistant to oral clomipramine tablets but not to an oral solution of amitriptyline. In the light of this case report, the potential mechanisms of drug resistance after digestive resection are discussed, including the importance of drug monitoring. © 2011 Lippincott Williams & Wilkins, Inc.