Journal ClubIn Utero Exposure to Smoking and Newborn Neurobehavior How to Assess Neonatal Withdrawal Syndrome?Pichini, Simona PhD*; Garcia-Algar, Oscar MD, PhD† ‡ Author Information *Drug Research and Evaluation Department, Istituto Superiore di Sanità, Rome, Italy †Unitat de Recerca Infància i Entorn (URIE), Pediatric Service, Hospital del Mar ‡Universitat Autònoma, Barcelona, Spain Supported by “Dipartimento Nazionale per le politiche antidroga” della Presidenza del Consiglio dei Ministri. Reprints: Simona Pichini, Drug Control and Evaluation Department, Istituto Superiore di Sanità, V.le Regina Elena 299, 00161 Rome, Italy (e-mail: [email protected]). Received for publication February 9, 2006; accepted February 16, 2006 Therapeutic Drug Monitoring: June 2006 - Volume 28 - Issue 3 - p 288-290 doi: 10.1097/01.ftd.0000211809.81816.1b Buy Metrics Abstract Recent studies postulate neurotoxic effects of prenatal tabacco exposure, passive addiction, and neonatal nicotine withdrawal syndrome in newborns in utero exposed to maternal smoking. The neonatal withdrawal syndrome is characterized by irritability, tremors, and sleep disturbances, most typically observed in newborns of heavy smoking mothers. © 2006 Lippincott Williams & Wilkins, Inc.