ArticlePopulation Pharmacokinetics of Carbamazepine in Chinese Epilepsy PatientsJiao, Zheng; Zhong, Ming-kang; Shi, Xiao-jin; Hu, Min; Zhang, Jing-huaAuthor Information Hua Shan Hospital, Fu Dan University, Shanghai, 200040, People's Republic of China Received May 29, 2002; accepted November 13, 2002. Address correspondence and reprint requests to Ming-kang Zhong, Pharmacy Department, Hua Shan Hospital, Shanghai, P.R.China, 200040; E-mail: email@example.com This project was supported by `100 elite program' research grants from Shanghai Health Bureau (No.98BR009). Therapeutic Drug Monitoring: June 2003 - Volume 25 - Issue 3 - p 279-286 Buy Abstract Aim To investigate the pharmacokinetic profile of carbamazepine (CBZ) in Chinese epilepsy patients. Materials and Methods Serum samples through concentrations at steady state (n = 687) were collected prospectively from 585 patients during routine clinical care. Data were analyzed by the non-linear mixed-effect modeling (NONMEM) technique with a one-compartment model of first-order absorption and elimination. Results The important determinants of clearance (CL) were total body weight (TBW); dose; patient age over 65 years (E); and comedication with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA) when VPA daily dose was greater than 18 mg/kg. The final pharmacokinetic model for relative CL and apparent distribution volume (V) were:MATH Conclusion A population pharmacokinetic model was proposed to estimate the individual CL for Chinese patients receiving CBZ in terms of patient's dose, TBW, and comedications to establish a priori dosage regimens. © 2003 Lippincott Williams & Wilkins, Inc.