ReviewsPopulation Pharmacokinetics/Pharmacodynamics Modeling: Parametric and Nonparametric MethodsJelliffe, Roger; Schumitzky, Alan; Van Guilder, MichaelAuthor Information Laboratory of Applied Pharmacokinetics, USC School of Medicine. Received February 2, 1999; accepted December 27, 1999. Address correspondence and reprint requests to Roger W. Jelliffe, Division of Geriatric Medicine, University of Southern California, 2250 Alcazar Street, CSC 134-B, Los Angeles, CA 90033. Therapeutic Drug Monitoring: June 2000 - Volume 22 - Issue 3 - p 354-365 Buy Abstract As clinicians acquire experience with the clinical and pharmacokinetic behavior of a drug, it is usually optimal to record this experience in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The role of population modeling is thus to describe and record clinical experience with the behavior of a drug in a certain group or population of patients or subjects. © 2000 Lippincott Williams & Wilkins, Inc.