ArticlesCylindrospermopsin, A Cyanobacterial Alkaloid: Evaluation of Its Toxicologic ActivityShaw, Glen R.*; Seawright, Alan A.*; Moore, Michael R.*; Lam, Paul K.S.†Author Information *National Research Centre for Environmental Toxicology, Archerfield, Queensland, Australia; †Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong Received September 21, 1999; accepted October 26, 1999. Address correspondence and reprint requests to G. R. Shaw, National Research Centre for Environmental Toxicology, PO Box 494, Archerfield Qld 4108, Australia. Therapeutic Drug Monitoring: February 2000 - Volume 22 - Issue 1 - p 89-92 Buy Abstract Summary: This paper describes the natural occurrence of the toxin, cylindrospermopsin, in two species of cyanobacteria found in Australia. The structure and chemical properties of this compound are described along with a nontoxic analog of cylindrospermopsin. The results of both intraperitoneal (IP) and oral dosing of mice show that hepatotoxicity is the main effect of cylindrospermopsin in vivo, but that a thrombohemorrhagic phenomenon is observed in a proportion of dosed animals. It has been shown that the toxin can be metabolized in vivo and that a bound metabolite occurs in the liver. Cytotoxicity experiments using cell cultures show that cylindrospermopsin is more cytotoxic to isolated rat liver hepatocytes than to other cell types. Risk assessment calculations show that guideline values for cylindrospermopsin in drinking water should lie in the low microgram per liter range. © 2000 Lippincott Williams & Wilkins, Inc.