Review: PDF OnlyPlacental and Milk Transfer of Chloroquine in HumansAkintonwa, Alade; Gbajumo, S. A.*; Biola Mabadeje, A. F.Author Information Departments of Pharmacology and University of Lagos, Lagos, Nigeria *Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria Therapeutic Drug Monitoring: June 1988 - Volume 10 - Issue 2 - p 147-149 Buy Abstract Summary: The placental and milk transfer of chloroquine was studied in seven subjects and six subjects, respectively. Seven pregnant women at term were administered chloroquine phosphate (5 mg/kg) i.m. The maternal blood and arterial and venous umbilical cord blood were obtained during delivery. The maternal chloroquine blood levels varied from 0.438 to 1.193 μg/ml. The venous cord blood ranged from 0.607 to 0.869, whereas the arterial levels ranged from 0.480 to 0.905 μg/ml. Six subjects who were administered chloroquine phosphate (5 mg/kg) postpartum had chloroquine milk levels of 0.192–0.319 μg/ml. The milk:blood ratio ranged from 0.268 to 0.462. Chloroquine readily crossed the placenta and was excreted into the breast milk. © Lippincott-Raven Publishers.