The role of enriched autologous plasmas in androgenetic alopecia (AGA) management is emerging in recent literature.
In this prospective study, the authors aimed to confirm that the induction of a minor local trauma immediately followed by injections of an enriched plasma made of a strongly concentrated platelet fraction, a robust white cell presence, concentrated fibrinogen, and other plasma proteins (injectable leukocyte platelet-rich fibrin [iL-PRF]) could be able to produce positive clinical results in patients with AGA.
A 2-injection regimen was instituted, with a 3-month interval between the 2 interventions. A treatment group (TG) and a control group (CG) were instituted. Macrophotographs were taken at baseline and after 6 months, and rated by 5-people expert panel (blinded to this assignment) using the 15-point scale proposed by Jaeschke to evaluate the clinical change.
Overall, TG showed better scores compared with the CG in all 5 classes of global physician assessment at baseline, all age groups, and in both sexes, and such differences always reached statistical significance. A greater severity at baseline showed a larger improvement after treatment in the TG.
This study provides preliminary evidence that the biological composition of the iL-PRF is of crucial importance in ensuring a good degree of clinical efficacy in patients with AGA.
*Plastic Surgery and Regenerative Surgery Unit, IDI-IRCCS, FLMM, Rome, Italy;
†Dermatology Unit, “Cristo Re” General Hospital, Rome, Italy;
‡Dermatological Day Surgery Unit, IDI-IRCCS, FLMM, Rome, Italy;
§Clinical Epidemiology Unit, IDI-IRCCS, FLMM, Rome, Italy
Address correspondence and reprint requests to: Andrea Paradisi, MD, Dermatology Unit, “Cristo Re” General Hospital, Via delle Calasanziane 25, 00168 Rome, Italy, or e-mail: aparad78@gmail.com
This work has been supported in part by the “Progetto Ricerca Corrente—2016” of the Italian Ministry of Health.
The authors have indicated no significant interest with commercial supporters.
