Surgical site infection (SSI) is mainly due to endogenous bacteria. Topical decolonization is a preoperative intervention currently advised for proven nasal carriers of Staphylococcus aureus (S. aureus).
The authors assessed whether topical decolonization could be of benefit for patients who are not nasal carriers of S. aureus.
The authors performed a randomized controlled trial of S. aureus nasal swab–negative patients. Five days before Mohs surgery topical decolonization with nasal mupirocin and chlorhexidine, body wash was started. The control group had no intervention.
In the week after Mohs surgery, the infection rate in the intervention group was 2% (n = 661, 14) and that of the control group was 4% (n = 689, 29).
Topical decolonization reduces SSI in nasal swab–negative Mohs surgery patients.
*All authors are affiliated with Oxford Dermatology, Perth, Western Australia, Australia
Address correspondence and reprint requests to: Harvey Smith, MD, FACD, Oxford Dermatology, First Floor Suite 4A, 416-418 Oxford Street, Mount Hawthorn, Perth 6016, Western Australia, or e-mail: email@example.com
The study was partly funded by a grant from the Australasian College of Dermatologists.
The authors have indicated no significant interest with commercial supporters.