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Swept-Source Optical Coherence Tomography–Supervised Biopsy

Xu, Qiuyun, MSc*; Adabi, Saba, PhD*; Clayton, Anne, PhD*; Daveluy, Steven, MD†,‡; Mehregan, Darius, MD; Nasiriavanaki, Mohammadreza, PhD*,†,‡

doi: 10.1097/DSS.0000000000001475
Original Article

BACKGROUND Currently, only skin biopsy can provide definitive histological confirmation for the diagnosis of skin diseases. To improve the diagnostic accuracy and to assist the dermatologist, various imaging techniques have been added to the examination of skin. Among all these techniques, the recent advances in optical coherence tomography (OCT) have made it possible to image the skin up to 2 millimeters in depth.

OBJECTIVE To testify the feasibility of OCT imaging in skin biopsy, the authors investigated the OCT imaging for real-time visualization of needle insertion and punch biopsy techniques in both a tissue phantom and biological tissue.

MATERIALS AND METHODS A swept-source OCT with 1,305-nm central wavelength was used in this study. The euthanized mouse was used for real-time visualization of needle insertion. A gelatin phantom with India ink was used to demonstrate the punch biopsy using OCT.

RESULTS Optical coherence tomography can provide guidance for skin injections as well as real-time imaging to assist in the performance of punch biopsy.

CONCLUSION Optical coherence tomography holds potential not only as a diagnostic tool in dermatology. It can also allow for visualization for more accurate drug delivery, and noninvasively assess the response to treatment.

*Department of Biomedical Engineering, Wayne State University, Detroit, Michigan;

Department of Dermatology, Wayne State University School of Medicine, Detroit, Michigan;

Molecular Imaging Department, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan

Address correspondence and reprint requests to: Mohammadreza Nasiriavanaki, PhD, Department of Biomedical Engineering, Wayne State University, 818 West Hancock Street, Detroit, MI 48201, or e-mail:

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the full text and PDF versions of this article on the journal's Web site (

Supported by the Wayne State Startup fund.

The authors have indicated no significant interest with commercial supporters.

© 2018 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
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