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Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

Alves, Rubina MD; Grimalt, Ramon MD, PhD

doi: 10.1097/DSS.0000000000000665
Original Article

BACKGROUND Platelet-rich plasma (PRP) was identified as having a beneficial effect in alopecia and has been postulated as a new therapy for androgenetic alopecia (AGA).

OBJECTIVE To assess the efficacy of PRP for the treatment of AGA.

MATERIALS AND METHODS This was a randomized, placebo-controlled, double-blind study in 25 patients with AGA. Platelet-rich plasma was injected in half-head and the other half-head with placebo. Each patient received a total of 3 treatments of PRP, 1 month apart.

RESULTS Six months after the first treatment with PRP, significant differences were seen in mean anagen hairs (67.6 ± 13.1), telogen hairs (32.4 ± 13.1), hair density (179.9 ± 62.7), and terminal hair density (165.8 ± 56.8) when compared with baseline (p < .05). Platelet-rich plasma was also found to increase hair density when comparing with the control side (p < .05). For the first time, the authors found a correlation between anagen hairs and patients >40 years and beginning of AGA ≥25 years old (p < .05) and hair density and male sex, age ≤40 years, positive family history of AGA and >10 years of duration of the disease (p < 0.05).

CONCLUSION Application of PRP showed a positive effect on AGA and could be regarded as an adjuvant therapy for AGA.

Department of Dermatology, Universitat Internacional de Catalunya, Barcelona, Spain

Address correspondence and reprint requests to: Rubina Alves, MD, Universitat Internacional de Catalunya, Estrada Monumental, 364 3F, Funchal, Portugal 9000-100, or e-mail: rubinaalves@gmail.com

The authors have indicated no significant interest with commercial supporters.

© 2016 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
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