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Clinical Experience With 11,460 mL of a 20-mg/mL, Smooth, Highly Cohesive, Viscous Hyaluronic Acid Filler

Humphrey, Shannon MD, FRCPC, FAAD*; Carruthers, Jean MD, FRCSC (Ophth); Carruthers, Alastair MD, FRCPC*

doi: 10.1097/DSS.0000000000000434
Original Article

BACKGROUND A 3-dimensional approach to facial rejuvenation restores volume lost over time. Hyaluronic acid (HA) filling agents provide long-lasting correction with minimal side effects and a high level of patient satisfaction. The newest HA formulation is a 20-mg/mL smooth cohesive filler (Juvéderm Voluma [HA-V]) that combines both low- and high-molecular-weight HA for more efficient cross-linking and greater lift capabilities.

OBJECTIVE To document the clinical experience with HA-V over the course of 68 months.

MATERIALS AND METHODS The authors conducted a retrospective chart review of patients who received HA-V for facial augmentation between February 1, 2009, and October 1, 2014. Clinical results were assessed 2 weeks after initial treatment, with touch-ups performed as necessary. Color photographs were taken before and after treatment, and adverse events were documented.

RESULTS Over 68 months, the authors treated 2,342 patients with 11,460 mL of HA-V. Aesthetic results lasted upwards of 12 months, and most side effects were transient and mild. Three patients developed signs of vascular compromise that was promptly treated and resolved within 2 months. Twenty-one patients (<0.5%) experienced late-onset, temporary, nontender nodules that were successfully managed with conservative measures.

CONCLUSION Easy to use and well tolerated, HA-V is ideally formulated for soft-tissue augmentation in the face, with clinical effects lasting 12 months or longer.

Departments of *Dermatology and Skin Science, and

Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada

Address correspondence and reprint requests to: Shannon Humphrey, MD, FRCPC, FAAD, Suite 820, 943 West Broadway, Vancouver, BC, Canada V5Z 4E1, or e-mail:

S. Humphrey, J. Carruthers, and A. Carruthers are consultants, investigators, and/or speakers for Allergan.

© 2015 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
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