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Volumizing with a 20-mg/mL Smooth, Highly Cohesive, Viscous Hyaluronic Acid Filler and Its Role in Facial Rejuvenation Therapy

CARRUTHERS, JEAN MD1; CARRUTHERS, ALASTAIR MD2; TEZEL, AHMET PHD3; KRAEMER, JENNIFER BSC (HONS), MSc4; CRAIK, LINDSAY BA, BAA4

doi: 10.1111/j.1524-4725.2010.01778.x
ORIGINAL ARTICLES
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BACKGROUND The new 20 mg/mL hyaluronic acid (HA) dermal filler is a smooth, highly cohesive, viscous formulation developed to restore volume in aesthetic facial rejuvenation.

OBJECTIVE Evaluate clinical experience with 20 mg/mL HA dermal filler to date and comment on its current and potential uses within the facial rejuvenation treatment paradigm.

METHODS AND MATERIALS In this paper, the authors review the unique physical and chemical properties of 20 mg/mL HA dermal filler as well as clinical experience with the product to date.

RESULTS Overall, the 20 mg/mL smooth, cohesive, viscous HA filler was especially effective in restoring volume in the malar region and chin. Volume loss resolved significantly in patients in clinical trials1 and treatment effects were observed to be maintained from six to 18 months.2

Physicians reported the agent was highly effective as well as easy to inject, sculpt and mold. The treatment was generally well tolerated and no instances of product migration from the injection site have been reported. Patient satisfaction was high, with the vast majority of trial participants acknowledging they would return for additional treatment and recommend the treatment to friends.1,2

CONCLUSION Initial experience shows the 20 mg/mL smooth, cohesive, viscous HA filler to be a useful addition to the facial rejuvenation armamentarium when used both alone and in combination with BTX-A.

This activity was supported by an educational grant provided by Allergan, Inc. Drs. Alastair and Jean Carruthers are consultants for Allergan, Inc. Editorial support was provided by IntraMed. Jennifer Kraemer and Lindsay Craik are editorial assistants for IntraMed.

1Department of Ophthalmology and Visual Sciences;2Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada;3Product Development, Allergan Inc., Santa Barbara, California;4IntraMed Educational Group, New York, New York;

Address correspondence and reprint requests to: Jean Carruthers, MD, Suite 820 - 943 West Broadway, Vancouver, BC, Canada V5Z 4E1, or e-mail: drjean@carruthers.net

© 2010 by the American Society for Dermatologic Surgery, Inc.
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