Photodynamic Therapy for the Treatment of Squamous Cell Carcinoma Using Benzoporphyrin Derivative : Dermatologic Surgery

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Photodynamic Therapy for the Treatment of Squamous Cell Carcinoma Using Benzoporphyrin Derivative

MARCUS, JEFFREY MD, MPH1; GLASSBERG, EDWARD MD1; DIMINO-EMME, LYNN MD1; YAMAMOTO, RICHARD MD1; MOY, RONALD L. MD1; VARI, SANDOR G. MD1; PAPAIOANNOU, THANASSIS MS1; PERGADIA, VANI R. MS1; SNYDER, WENDY J. MS1; GRUNDFEST, WARREN S. MD1; LASK, GARY P. MD1

Author Information

1 From the Division of Dermatology (JM, EG, RLM, GPL), UCLA Medical Center, Los Angeles, California; the Division of Dermatology (EG, LDE, RY, GPL), UCLA-Harbor Medical Center, Los Angeles, California; and the Laser Research and Technology Development Department (SGV, TP, VRP, WJS, WSG), Cedars-Sinai Medical Center, Los Angeles, California.

Address correspondence and reprint requests to: Jeffrey Marcus, MD, MPH, Division of Dermatology, UCLA Medical Center, 200 UCLA Medical Plaza, Suite 450, Los Angeles, CA 90024.

The Journal of Dermatologic Surgery and Oncology 20(6):p 375-382, June 1994. | DOI: 10.1111/j.1524-4725.1994.tb02621.x

Abstract

background. 

Photodynamic therapy (PDT) involves laser light excitation of a tumor-localizing photosensitizer to destroy neoplasms. Benzoporphyrin derivative (BPD) is a new photosensitizer with several favorable characteristics.

objective. 

Studies were designed to: 1) assess the efficacy of BPD-mediated PDT in treating in vivo squamous cell carcinomas (SCC); 2) obtain dosimetry data for BPD and laser parameters; and 3) establish clinical and histologic correlates of BPD-induced tumor regression.

methods. 

Human SCC was implanted into nude mice. One group received BPD followed by laser light of 150 J/cm2 from an argon-pumped dye laser at 690 nm. Three control groups included laser energy alone, BPD alone, and no treatment.

results. 

At day 21 posttreatment only PDT-treated tumors showed a statistically significant decrease in tumor volume and complete cure rate. Clinical resolution (scar) correlated perfectly with histologic resolution (scar).

conclusions. 

Human SCC in a nude mouse model responds to BPD-mediated PDT.

© Lippincott-Raven Publishers.

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