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Basal Cell Carcinoma and Collagenase

GOSLEN, BLAKE J. M.D.¹; BAUER, EUGENE A. M.D.¹

¹ J. Blake Goslen, M.D., Assistant Professor, and Eugene A. Bauer, M.D., Professor, are from the Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

Address reprint requests to J. Blake Goslen, M.D., Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.

The Journal of Dermatologic Surgery and Oncology 12(8):p 812-817, August 1986. | DOI: 10.1111/j.1524-4725.1986.tb01987.x

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Abstract

The interaction of connective tissue stroma and epithelial cutaneous cancer is an active area of investigation in dermatology. Studies summarized here explore the role of collagenase in basal cell carcinoma (BCC) invasiveness. Evidence is presented to support the role of a cytokine or cytokines secreted by BCCs that stimulate collagenase production by surrounding stromal fibroblasts. Prospects for further research in this area are proposed.