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Inhibition of Wound Healing by Topical Steroids

MARKS, JAMES G. JR. M.D.¹; CANO, CHERYL²; LEITZEL, KIM²; LIPTON, ALLAN M.D.³

¹ Assistant Professor of Medicine, Department of Dermatology, Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

² Research Technicians, Department of Medicine, Division of Oncology, Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

³ Professor of Medicine and Microbiology, Chief Division of Oncology, Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

Address reprint requests to James G. Marks, Jr., M.D., Division of Dermatology, Hershey Medical Center, Hershey, PA 17033.

The Journal of Dermatologic Surgery and Oncology 9(10):p 819-821, October 1983. | DOI: 10.1111/j.1524-4725.1983.tb00738.x

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Abstract

A new animal model was used to study the effect of topical agents on wound healing. A weak- (hydrocortisone cream 1%) and medium-strength (fluocino-lone acetonide ointment 0.025%) steroid and their vehicles were applied to full-thickness skin wounds placed on the backs of female Syrian hamsters. Wound healing was significantly retarded by both steroids when compared to their vehicles. Fluocinolone had a greater inhibitory effect than hydrocortisone.