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Skin Sensitization Induction Risk Assessment of Common Ingredients in Commercially Available Cleansing Conditioners

Monnot, Andrew D., PhD*; Towle, Kevin M., ScM*; Warshaw, Erin M., MD†‡; Fung, Ernest S., PhD§; Novick, Rachel M., PhD*; Paustenbach, Dennis J., PhD; Drechsel, Derek A., PhD

doi: 10.1097/DER.0000000000000445
STUDIES
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Background An essential step in ensuring the toxicological safety of cosmetic or personal care products is the evaluation of the skin sensitizing potential of product ingredients.

Objective We used a standardized protocol from cosmetic trade industry and consumer safety groups to evaluate the sensitization potential of ingredients in 3 commercially available cleansing conditioners.

Methods A total of 33 ingredients were evaluated. Each ingredient underwent (1) dermatological evaluation, (2) in silico analysis for irritation and sensitization potential, and (3) a literature evaluation to determine risk of sensitization. Consumer exposure level was compared with the weight-of-evidence no-expected sensitization induction level for the constituent. If a no-expected sensitization induction level for a specific ingredient was not available, the dermal sensitization threshold approach was used. A margin of safety was calculated for each constituent.

Results The margins of safety for all evaluated ingredients in the cleansing conditioners were greater than 1.

Conclusions This analysis indicates that exposure to the individual ingredients present in these cleansing conditioners would not be expected to induce dermal sensitization in a consumer under the examined exposure scenario.

From the *Cardno ChemRisk, San Francisco, CA;

Dermatology Department, University of Minnesota; and

Park Nicollet, Minneapolis, MN;

§Cardno ChemRisk, Aliso Viejo, CA;

Cardno ChemRisk, Jackson, WY; and

Cardno ChemRisk, Boulder, CO.

Address reprint requests to Andrew D. Monnot, PhD, Cardno-ChemRisk, 235 Pine St, Ste 2300, San Francisco, CA 94104. E-mail: Andrew.monnot@cardno.com.

Funding for the research and preparation of this article was provided by WEN by Chaz Dean.

A.D.M., K.M.T., D.A.D., E.S.F., R.M.N., and D.J.P. are employed by Cardno ChemRisk, a consulting firm that provides scientific advice to the government, corporations, law firms, and various scientific/professional organizations. Cardno ChemRisk and E.M.W. have been engaged by WEN by Chaz Dean, which produces personal care products such as cleansing conditioners. This article was prepared and written exclusively by the authors without review or comment by any outside entity. It is possible that this work will be relied upon in litigation.

© 2019 American Contact Dermatitis Society
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