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Effective Use of Dupilumab in Managing Systemic Allergic Contact Dermatitis

Joshi, Shyam R., MD; Khan, David A., MD

doi: 10.1097/DER.0000000000000409

Allergic contact dermatitis to metals has become increasingly recognized in patients with endovascular implants. The ACD can lead to in-stent restenosis as well as a prominent eczematous reaction overlying the implant, often necessitating its removal. We present a case of refractory allergic contact dermatitis to nickel in a 44-year-old man with numerous endovascular stents and vascular clips. He developed numerous adverse effects of systemic therapy to manage his symptoms including recurrent infections leading to frequent hospitalizations. He was effectively transitioned to dupilumab, a monoclonal antibody against the IL-4α subunit currently approved by the Food and Drug Administration in the management of atopic dermatitis, with an improvement in symptoms and a reduction in infection rate.

From the University of Texas Southwestern Medical Center, Dallas.

Address reprint requests to Shyam R. Joshi, MD, Division of Allergy & Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8859. E-mail:

The authors have no funding or conflicts of interest to declare.

© 2018 American Contact Dermatitis Society
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