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Skin Ceramide Profile in Children With Atopic Dermatitis

Shen, Chun-Ping, MD*; Zhao, Mu-Tong, MD*; Jia, Zhi-Xin, PhD; Zhang, Jin-Lan, PhD; Jiao, Lei, MD*; Ma, Lin, MD*

doi: 10.1097/DER.0000000000000392

Background Atopic dermatitis (AD) is a common disease, which involves a disruption of the skin barrier function. Skin ceramide (CER) composition, which plays crucial roles in maintaining the barrier function of the stratum corneum, is changed in patients with AD.

Objective The aim of this study was to identify and quantify skin CER subclasses in association with disease severity in pediatric patients with AD.

Methods Two hundred thirteen patients were entered into the observational study. We compared their CER profiles using normal-phase high-performance liquid chromatography coupled with dynamic multiple reaction monitoring mass spectrometry.

Results In total, 12 subclasses of CERs were identified. We found that 2 subclasses, that is, CER[AS] and CER[NS], were elevated (P = 0.007 and 0.012, respectively) and correlated with Severity Scoring of Atopic Dermatitis (P = 0.004 and 0.004, respectively).

Conclusions Skin CER abundances are changed in children with AD compared with control subjects.

From the *Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health; and

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Address reprint requests to Lin Ma, MD, Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China, No. 56 S Li Shi Rd, Xi Cheng District, Beijing, 100045, China. E-mail:

L.M. has received honoraria from Beijing Natural Science Foundation (7154197) and Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201601). The other authors have no funding or conflicts of interest to declare.

C.-P.S. and M.-T.Z. contributed equally to the work.

© 2018 American Contact Dermatitis Society
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