Kathon CG is a commonly used cosmetic-grade preservative that contains active ingredients methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI).
The aim of the study was to perform a skin sensitization induction risk assessment of daily exposure to Kathon CG after use of various personal care and cosmetic products.
We calculated an estimated daily consumer exposure level for rinse-off and leave-on products using the amount of product applied per application, number of applications per day, a retention factor, the MCI/MI concentration, and body surface area values. We assumed that the products contained the maximum recommended safe concentration of MCI/MI: 15 ppm in rinse-off products and 7.5 ppm in leave-on products. We compared estimated consumer exposure levels with the no expected sensitization induction level for MCI/MI and applied sensitization assessment factors to calculate product-specific margins of safety (MOSs).
The MOSs for rinse-off products ranged from 5 to 63, whereas the MOSs for leave-on products ranged from 0.03 to 1.49. Overall, our results provide evidence that some leave-on products containing the maximum recommended safe concentration of Kathon CG may increase the risk of sensitization induction due to exposure to MCI/MI. In contrast, rinse-off products were not associated with a potential increased risk of skin sensitization induction.
From the *Cardno ChemRisk, San Francisco, CA;
†Cardno ChemRisk, Boulder, CO;
‡Dermatology Department, University of Minnesota;
§Park Nicollet, Minneapolis, MN,
∥Cardno ChemRisk, Aliso Viejo, CA; and
¶Cardno ChemRisk, Jackson, WY.
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K.M.T., D.A.D., E.S.F., R.M.N., D.J.P., and A.D.M. are employed by Cardno ChemRisk, a consulting firm that provides scientific advice to the government, corporations, law firms, and various scientific/professional organizations. Cardno ChemRisk and E.M.W. have been engaged by WEN by Chaz Dean, which produces personal care products that may contain Kathon CG.
The study was supported by WEN by Chaz Dean.
This article was prepared and written exclusively by the authors without review or comment by any outside entity. It is possible that this work will be relied upon in litigation.