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Immune Dysregulation in the Pathogenesis of Atopic Dermatitis

Gavrilova, Tatyana, MD

doi: 10.1097/DER.0000000000000340

Atopic dermatitis is a multifactorial disease. Epidermal barrier impairment often plays the initial role in the initiation of the disease. Immune dysregulation of the innate and adaptive immunity plays a central role in the pathogenesis of atopic dermatitis. Alteration of the epidermal microbiome-host interaction serves a catalytic role in propagating this immune response. The understanding of this disease pathogenesis is important in generating treatment options, especially those such as biologic agents that can target a specific immune pathway.

From the Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

Address reprint requests to Tatyana Gavrilova, MD, Montefiore Medical Center, Albert Einstein College of Medicine, 3415 Bainbridge Ave, Bronx, NY 10467. E-mail:

The author has no funding or conflicts of interest to declare.

© 2018 American Contact Dermatitis Society
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