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Contact Allergy to Neem Oil

de Groot, Anton MD, PhD*; Jagtman, Berend A. MD, PhD; Woutersen, Marjolijn PhD

doi: 10.1097/DER.0000000000000309

A case of allergic contact dermatitis from neem oil is presented. Neem oil (synonyms: Melia azadirachta seed oil [INCI name], nim oil, margosa oil) is a vegetable (fixed) oil obtained from the seed of the neem tree Azadirachta indica by cold pressing. Contact allergy to neem oil has been described previously in only 3 patients. The allergen(s) is/are unknown.

From the *Acdegroot Publishing, Wapserveen; †VieCurie Medisch Centrum, Venlo; and ‡National Institute for Public Health and the Environment Centre for Safety of Substances and Products, Bilthoven, the Netherlands.

Address reprint requests to Anton de Groot, MD, PhD, Acdegroot Publishing, Schipslootweg 5 8351 HV, Wapserveen, the Netherlands. E-mail:;

The authors have no funding or conflicts of interest to declare.

The data in this article are presented here in the framework of CESES (Consumer Exposure Skin Effects and Surveillance), a Dutch Cosmetovigilance system monitoring the adverse effects of cosmetics in the Netherlands. CESES is initiated and executed by the National Institute for Public Health and the Environment and the Netherlands Food and Consumer Product Safety Authority. The project is sponsored by the Dutch Ministry of Health, Welfare and Sports. All authors participate in this project.

© 2017 American Contact Dermatitis Society
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