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Contact Allergy Cross-reactions: Retrospective Clinical Data and Review of the Literature

Scheman, Andrew MD; Hipolito, Ricky MD; Severson, David; Youkhanis, Nineveh BS

doi: 10.1097/DER.0000000000000254

We discuss cross-reactions that can occur when a patient allergic to a specific allergen also reacts to a similar allergen. Currently, The American Contact Dermatitis Society Contact Allergy Management Program, which allows physicians to identify safe products for their patients, uses a 10% threshold to distinguish significant cross-reactors. New clinical data from a patch testing center along with previous data in the literature are analyzed to help determine whether current cross-reactor definitions are reasonable or should be altered.

From the *Northwestern University Medical Center, Chicago, IL; †Department of Health, Research Institute for Tropical Medicine, Muntinlupa, Philippines; and §University of Illinois, Urbana-Champaign, IL.

Address reprint requests to Andrew Scheman, MD, Northwestern University Medical Center, 1535 Lake Cook Rd, Suite 401, Northbrook, IL 60062. E-mail:

The authors have no funding or conflicts of interest to declare.

© 2017 American Contact Dermatitis Society
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