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Hypersensitivity Reactions to Titanium: Diagnosis and Management

Wood, Megan M. BA, RDMS*; Warshaw, Erin M. MD, MS

doi: 10.1097/DER.0000000000000091

Titanium is notable for its biocompatibility and is used as biologic implant material across surgical specialties, especially in metal-sensitive individuals. However, rare cases of titanium hypersensitivity reactions are reported in the literature. This article discusses the properties and biological behavior of titanium and provides a thorough review of the literature on reported cases, diagnostic techniques, and approach to management of titanium hypersensitivity.

From the *Department of Dermatology, University of Minnesota Medical School; and the †Department of Dermatology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN.

Address reprint requests to Megan M. Wood, BA, RDMS, University of Minnesota Medical School (MS4), 6th floor Mayo Bldg, 420 Delaware Street SE, Minneapolis, MN 55455. E-mail:

The authors have no funding or conflicts to declare.

This material is the result of work supported with resources and the use of facilities at the Minneapolis Veterans Affairs Medical Center. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the US Government.

© 2015 American Contact Dermatitis Society
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