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Young Individuals With Atopic Disease and Asthma or Rhinoconjunctivitis May Have Clinically Relevant Contact Allergies

Netterlid, Eva PhD*†; Hindsén, Monica PhD*; Ekqvist, Susanne PhD*; Henricson, Kent Åke MD; Bruze, Magnus Prof, MD, PhD*

doi: 10.1097/DER.0000000000000037

Background Children and adolescents with atopic disease who have allergic asthma and/or rhinitis with and without atopic dermatitis may have hidden, clinically relevant contact allergies.

Objective The objective of this study was to survey contact allergies in children and adolescents who had been offered allergen-specific immunotherapy and accepted (exposed)/not accepted (unexposed) such treatment.

Methods Thirty-seven exposed and 24 unexposed individuals with atopic disease were patch tested with a standard series supplemented with aluminum chloride hexahydrate, an empty Finn Chamber, and 8 antigen preparations.

Results In the exposed group, 18 allergies were detected in 13 individuals with atopic disease when excluding reactions to aluminum and antigen preparations, whereas the corresponding figures for the unexposed group were 9 and 6, respectively (non–significant difference). Independent of the allergen-specific immunotherapy, significantly more (P = 0.013) individuals with atopic dermatitis had at least 1 contact allergy. Clinically relevant allergies were represented by sesquiterpene lactone mix, para–tertiary butylphenol-formaldehyde resin, tixocortol pivalate, and colophony.

Conclusions Clinically relevant contact allergies are not uncommon in children and adolescents with atopic disease, which is why patch testing always should be considered in the management of dermatitis in individuals with atopic disease.

From the *Department of Occupational and Environmental Dermatology, Skåne University Hospital; †Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö; and ‡Department of Paediatrics, County Hospital, Halmstad, Sweden.

Address reprint requests to Eva Netterlid, PhD, Department of Clinical Sciences in Malmö, Occupational and Environmental Dermatology Unit, Faculty of Medicine, Lund University, SUS Malmö, Jan Waldenströms gata 16 plan 5, SE-205 02 Malmö, Sweden. E-mail:

The authors have no funding or conflicts of interest to declare.

© 2014 American Contact Dermatitis Society
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