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Cutaneous Hypersensitivity to Gluten

Tammaro, Antonella; Narcisi, Alessandra MD; De Marco, Gabriella; Persechino, Severino


We enrolled 14 female patients (aged 12-60 years) affected by celiac disease (confirmed by duodenal biopsy), presenting dermatologic eczematous lesions involving their face, neck, and overall arms, after application of gluten-containing emollient cream, bath, or face powder, or after contact with foods containing wheat and durum wheat. Five patients resulted positive to patch-by-patch with wheat and durum wheat (mild to moderate positivity) with erythema and vesicles, in correspondence of their sites of application. Utilizing gluten-free cream and bath, and wearing gloves before hand contact with food-containing wheat, in their common life, these patients showed an improvement of their cutaneous lesions and no relapses of dermatitis for a 6-month follow-up period.

From the U.O.C. Dermatology, NESMOS Department, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.

Address reprint requests to Alessandra Narcisi, MD, U.O.C. Dermatology II Unit, Sapienza University, Via di Grottarossa, 1039, 00189 Rome, Italy. E-mail:

© 2012 American Contact Dermatitis Society
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