This clinical review article presents clinical and scientific data on cobalt sensitization and dermatitis. It is concluded that cobalt despite being a strong sensitizer and a prevalent contact allergen to come up on patch testing should be regarded as a very complex metal to test with. Exposure data together with clinical data from metal workers heavily exposed to cobalt suggest that patch-test reactions are sometimes false positive and that patch testers should carefully evaluate their clinical relevance.
From the National Allergy Research Centre, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, University of Copenhagen, Hellerup, Gentofte, Denmark.
Address reprint requests to Jacob P. Thyssen, MD, PhD, National Allergy Research Centre, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, University of Copenhagen, Ledreborg Allé 40, 1. 2820 Gentofte, Denmark. E-mail: email@example.com.
Unrestricted financial support of Jacob Thyssen’s salary was received from The Leo Pharma Research Foundation, The Else and Mogens Wedell-Wedellsborgs Foundation, Jacob Madsen and wife Olga Madsens Foundation, the Gerhard Brφndsteds travel grant, and the Danish physician’s insurance under Codan/SEB Pension.
Dr Thyssen has sold the cobalt spot test to SmartHealth (Phoenix, Ariz) after its development and will receive royalty fee annual net sales of the spot test.
In memory of Alexander Fischer.