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A 10-Year Review of p-Phenylenediamine Allergy and Related para-Amino Compounds at the Ottawa Patch Test Clinic

LaBerge, Lauren; Pratt, Melanie; Fong, Bensun; Gavigan, Genevieve

doi: 10.2310/6620.2011.11044

Background: p-Phenylenediamine (PPD) is an important allergen; 5.0% of patients tested positive to PPD when patch-tested, according to the North American Contact Dermatitis Group. Hair dyes are the main source of exposure.

Objective: To assess the significance of PPD allergy at the Ottawa Patch Test Clinic.

Methods: We assessed the epidemiology of PPD allergies and determined the cross-reactivity with other para-amino compounds. Charts of patients visiting the Ottawa Patch Test Clinic between May 1997 and July 2009 were reviewed.

Results: One hundred thirty-four patients were found to have a contact allergy to PPD; 75.4% were female, 24.6% were male, 13.4% were hairdressers, 18.7% had a history of atopy, 90.3% were sensitized by hair dye, 2.2% were sensitized by henna tattoos, and 7.5% were sensitized by other sources. Positive patch-test reactions to textile dyes were seen in 24.6%, 7.5% reacted to benzocaine, 6.0% reacted to sulfa drugs, 1.5% reacted to isopropyl-para-phenylenediamine, and 1.5% reacted to para-aminobenzoic acid.

Conclusions: PPD is an important source of allergic contact allergy. Our results show a significant relationship of PPD with other related para-amino compounds.

From the Department of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.

Address reprint requests to Lauren LaBerge, University of OttawaDermatology, 1053 Carling Ave., Ottawa, ON, Canada K1Y 1J8.

©2011American Contact Dermatitis Society, All Right Reserved
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