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Allergy to Methyldibromoglutaronitrile/Phenoxyethanol (Euxyl K 400): Regulatory Issues, Epidemiology, Clinical Characteristics, and Management

Aakhus, Angela E.; Warshaw, Erin M.

doi: 10.2310/6620.2011.10081

Methyldibromoglutaronitrile/phenoxyethanol (Euxyl K 400) is a preservative found in both personal care products and industrial sources. Although Euxyl K 400 initially appeared to have low sensitizing potential, increased prevalence of contact allergy to Euxyl K 400 led to regulatory intervention. This review summarizes the history, epidemiology, and management of contact allergy to Euxyl K 400. Issues related to patch-test preparations are also discussed.

From the Department of Dermatology, University of Minnesota School of Medicine, Minneapolis, MN, and the Minneapolis Veterans Affairs Medical Center - Center for Chronic Disease Outcomes Research, Minneapolis, MN.

Reprints not available.

© 2011 Decker Publishing Inc.
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